Evidence map›Paper›PMID 41198843›Full record

ArticleScientific reports2025

The role of thrombospondin-1 in trehalose-induced autophagy and ocular hypertension in mice.

Choi-Ying Ling, Kit-Ying Choy, Hoi-Lam Li, Choi-Yee Tse, Wei-Ying Yang, Nga-Wai Wong, W Daniel Stamer, Chi-Wai Do, Dennis Yan-Yin Tse, Samantha Sze-Wan Shan

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Choi-Ying Ling *School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.
Kit-Ying Choy *School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.
Hoi-Lam LiOphthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Choi-Yee TseSchool of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.
Wei-Ying YangSchool of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.
Nga-Wai WongSchool of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.
W Daniel StamerDepartment of Ophthalmology, Durham, NC, USA.
Chi-Wai DoSchool of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.
Dennis Yan-Yin TseSchool of Optometry, The Hong Kong Polytechnic University, Hong Kong, China. dennis.tse@polyu.edu.hk.
Samantha Sze-Wan ShanSchool of Optometry, The Hong Kong Polytechnic University, Hong Kong, China. samantha.shan@polyu.edu.hk.

Funding

Health and Medical Research Fund 08191556Health and Medical Research Fund 20212781PolyU Internal Grant 1-BD6R
6 · The paper itself

Abstract

Prolonged use of dexamethasone (DEX) increases intraocular pressure (IOP) and the risk of glaucoma. Recent studies have shown that DEX upregulates thrombospondin-1 (THBS1) gene expression and induces dysregulation of macroautophagy/autophagy in primary human trabecular meshwork (hTM) cells. Trehalose, a natural disaccharide, activates autophagy and protects cells against environmental stresses. Here, we report that trehalose-induced autophagy enhanced outflow facility, reduced IOP, and protected against ocular hypertension in mice. We analyzed autophagy induction by trehalose in hTM cells. Our data demonstrated that trehalose transcriptionally upregulated prototypical autophagy related genes and activated autophagy through the downregulation of THBS1. Consistent with prior findings, the results indicated that THBS1 silencing or inhibition is a key cellular event for the regulation of aqueous humor outflow and IOP homeostasis. In conclusion, this study identified trehalose-induced autophagy as a protective mechanism against ocular hypertension which may have therapeutic potential.

Indexed as

AutophagyOcular HypertensionThrombospondin 1TrehaloseAnimalsAqueous HumorDexamethasoneDisease Models, AnimalHumansIntraocular PressureMaleMiceMice, Inbred C57BLTrabecular MeshworkDexamethasoneThbs1 protein, mouseThrombospondin 1TrehaloseAutophagyIntraocular pressureOcular hypertensionOutflow facilityThrombospondin-1Trehalose

Identifiers

PMID41198843
PMCPMC12592402

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.