Evidence map›Paper›PMID 41198727›Full record

ArticleScientific reports2025

Effects of hydroxy methionine analog iron chelate on growth performance, blood parameters, and iron metabolism in weaned piglets.

Yuemeng Fu, Jingzi Fang, Yilin Ge, Shuning Zhang, Yuhang Liu, Guohui Zhou, Xuejun Yuan, Ning Jiao, Yang Li, Weiren Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuemeng FuKey Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs, Shandong Agricultural University, Panhe Street 7, Tai'an, 271017, China.
Jingzi FangChangsha Xingjia Bio-Engineeriong Co., Ltd, Changsha, 410000, Hunan, China.
Yilin GeSDU-ANU Joint Science College, Shandong University, Wenhuaxilu 180, Weihai, 264209, China.
Shuning ZhangKey Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs, Shandong Agricultural University, Panhe Street 7, Tai'an, 271017, China.
Yuhang LiuKey Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs, Shandong Agricultural University, Panhe Street 7, Tai'an, 271017, China.
Guohui ZhouKey Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs, Shandong Agricultural University, Panhe Street 7, Tai'an, 271017, China.
Xuejun YuanCollege of Life Sciences and Technology, Shandong Agricultural University, Daizong Street 61, Tai'an, 271018, China.
Ning JiaoKey Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs, Shandong Agricultural University, Panhe Street 7, Tai'an, 271017, China.
Yang LiKey Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs, Shandong Agricultural University, Panhe Street 7, Tai'an, 271017, China.
Weiren YangKey Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs, Shandong Agricultural University, Panhe Street 7, Tai'an, 271017, China. wryang211@163.com.

Funding

Shandong Province Key R&D Program 2023TZXD041Shandong Province Modern Agricultural Industry Technology System Project SDAIT-08-04
6 · The paper itself

Abstract

This study aimed to investigate the effects of dietary hydroxy methionine analog iron chelate (Fe-HMA) as an iron source on the growth performance, blood parameters, and iron metabolism of weaned piglets. A 28-day trial was conducted using 120 weaned piglets that were randomly allocated to two treatment groups with different iron sources. The Fe-sulfate group received a diet containing 100 mg Fe/kg in the form of ferrous sulfate, while the Fe-HMA group received a diet with 50 mg Fe/kg in the form of Fe-HMA. Fe-HMA, as an iron source, did not significantly affect growth performance, but improved iron apparent digestibility and tissue deposition compared with the Fe-sulfate group. Additionally, Fe-HMA significantly enhanced erythrocyte-related indicators and regulated the serum iron metabolism markers. It also upregulated the relative expression of the iron metabolism-related genes ferroportin1 (FPN1) in the duodenum and hepcidin antimicrobial peptide (HAMP), ferritin light chain (FTL), and transferrin (TF) in the liver, while downregulating transferrin receptor (TFRC) expression in the liver. Replacing dietary inorganic iron with HMA-chelated iron improved iron metabolism in weaned piglets, suggesting its potential as an effective alternative source of iron in porcine nutrition.

Indexed as

IronIron Chelating AgentsMethionineAnimal FeedAnimalsCation Transport ProteinsDietary SupplementsDuodenumFerroportinFerrous CompoundsHepcidinsLiverSwineWeaningCation Transport ProteinsFerroportinFerrous Compoundsferrous sulfateHepcidinsIronIron Chelating AgentsMethionineChelated ironIron metabolismMethionine hydroxy analogTrace elementWeaned piglets

Identifiers

PMID41198727
PMCPMC12592463

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.