Evidence map›Paper›PMID 41198720›Full record

ArticleScientific reports2025

SERPINA1 gene regulates the tumorigenesis and progression of breast cancer through PI3K/AKT signaling pathway and tumor immune microenvironment.

Chuqi Lei, Wei Lu, Yuan Li, Huaiyu Yang, Ke Zhang, Nianchang Wang, Lixue Xuan, Changyuan Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chuqi Lei *Department of Breast Surgical Oncology, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, China.
Wei Lu *Department of Breast Surgical Oncology, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, China.
Yuan LiDepartment of Breast Surgical Oncology, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, China.
Huaiyu YangDepartment of Breast Surgical Oncology, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, China.
Ke ZhangDepartment of Breast Surgical Oncology, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, China.
Nianchang WangDepartment of Breast Surgical Oncology, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, China.
Lixue XuanDepartment of Breast Surgical Oncology, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, China. xuanlixuepumc@126.com.
Changyuan GuoDepartment of Pathology, National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. guocypumc@163.com.

Funding

Beijing Xisike Clinical Oncology Research Foundation Y-NESTLE2022MS-0036National Natural Science Foundation of China 82372078
6 · The paper itself

Abstract

This study aims to reveal the influence of SERPINA1 gene on the development, prognosis evaluation and immune environment changes of breast cancer. Cell lines with differential SERPINA1 expression were constructed. These models were used to explore its impact on the biological behavior of breast cancer cells. The expression of SERPINA1 in breast tumor tissues of patients undergoing surgery in our hospital was detected by immunohistochemistry to evaluate the regulatory effect of SERPINA1 gene on tumor microenvironment. The results found that the overexpression of SERPINA1 gene could significantly inhibit the proliferation and migration of breast cancer cells and promote apoptosis. Transcriptome sequencing analysis revealed that SERPINA1 may regulate the biological behavior of cells by affecting biological functional pathways such as adaptive immune response, natural killer cell-mediated cytotoxicity, and phosphatidylinositol signaling system

Indexed as

alpha 1-AntitrypsinBreast NeoplasmsCarcinogenesisPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionTumor MicroenvironmentApoptosisCell Line, TumorCell MovementCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansPTEN Phosphohydrolasealpha 1-AntitrypsinPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPTEN PhosphohydrolaseSERPINA1 protein, humanBreast cancerPI3K/AKTSERPINA1 geneTumor immune microenvironment

Identifiers

PMID41198720
PMCPMC12592430

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.