ArticleSchizophrenia (Heidelberg, Germany)2025
Temporal integration window of sensory processing as a neuropsychological marker for clinical high risk of psychosis.
Article in Schizophrenia (Heidelberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Early identification of individuals with clinical high risk (CHR) for psychosis relies heavily on subjective assessments, necessitating the exploration of objective markers to enhance diagnostic accuracy. This study aimed to evaluate the temporal integration window (TIW) of sensory processing in individuals with CHR, first-episode schizophrenia (FES), and healthy controls (HC) to assess its utility as an objective neuropsychological marker for identifying CHR individuals. Ninety participants (30 CHR, 30 FES, 30 HC) completed temporal order judgment of visual and auditory(TOJV and TOJA) and simultaneity judgment of the flash-beep (SJF) tasks. Unisensory (visual and auditory) thresholds and TIW were measured and compared across groups. Cognitive function was assessed using the MATRICS Consensus Cognitive Battery (MCCB). The associations between cognition with unisensory thresholds and TIW were analyzed. The TIW was significantly prolonged in both the CHR (336.95 ± 108.30 ms) and FES (413.15 ± 121.27 ms) groups compared to the HC group (229.95 ± 54.53 ms) (P < 0.05). Visual and auditory thresholds and TIW were negatively correlated with information processing speed and attention (both P < 0.05). Notably, TIW effectively discriminates across three groups. Compared to HC, each 50 ms increase in TIW was associated with a 2.3-fold increased risk of CHR (95% CI 1.27-4.28, P = 0.01; AUC = 0.81, 95% BCa CI 0.65-0.91). Similarly, it was associated with a 3.3-fold increased risk of FES (95% CI 1.78-6.34, P < 0.01; AUC = 0.94, 95% BCa CI 0.81-0.99). No correlations were observed between TIW and symptom severity in FES and CHR. Prolonged TIW in multisensory integration may serve as a promising objective neuropsychological marker for identifying individuals at CHR for psychosis.
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