Evidence map›Paper›PMID 41198662›Full record

ArticleNature communications2025

The locking mechanism of human TRPV6 inhibition by intracellular magnesium.

Arthur Neuberger, Alexey Shalygin, Irina I Veretenenko, Yury A Trofimov, Thomas Gudermann, Vladimir Chubanov, Roman G Efremov, Alexander I Sobolevsky

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Arthur Neuberger *Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-7744-6559
Alexey Shalygin *Walther-Straub Institute of Pharmacology and Toxicology, LMU Munich, Munich, Germany.
Irina I Veretenenko *Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.ORCID http://orcid.org/0009-0001-2828-8224
Yury A TrofimovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.ORCID http://orcid.org/0000-0003-2673-7281
Thomas GudermannWalther-Straub Institute of Pharmacology and Toxicology, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-0323-7965
Vladimir ChubanovWalther-Straub Institute of Pharmacology and Toxicology, LMU Munich, Munich, Germany. vladimir.chubanov@lrz.uni-muenchen.de.ORCID http://orcid.org/0000-0002-6042-4193
Roman G EfremovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. efremov@nmr.ru.ORCID http://orcid.org/0000-0002-5474-4721
Alexander I SobolevskyDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA. as4005@cumc.columbia.edu.ORCID http://orcid.org/0000-0001-5181-8644

Funding

Structure and Function of AMPA subtype ionotropic glutamate receptorsR01NS083660 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KURNIKOVA, MARIA G, SOBOLEVSKY, ALEXANDER · 2013 to 2022
$4.3M
Structure and function of Transient Receptor Potential ChannelsR01CA206573 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2017 to 2026
$3.8M
Single-Particle Cryo-EM Characterization of AMPA Receptor Functional StatesR01NS107253 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2018 to 2026
$3.5M
Structural and functional principles of activation and regulation of the transient receptor potential channel TRPV3.R01AR078814 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2022 to 2026
$2.8M
Structure and Function of Ionotropic Glutamate ReceptorsR37NS083660 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2024 to 2026
$1.7M
NCI NIH HHS R01 CA206573NIAMS NIH HHS R01 AR078814NINDS NIH HHS R01 NS083660NINDS NIH HHS R01 NS107253NINDS NIH HHS R37 NS083660U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA206573U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) AR078814
6 · The paper itself

Abstract

TRPV6 is a member of the vanilloid subfamily of transient receptor potential channels, which serves as the master regulator of Ca

Indexed as

Calcium Channel BlockersCalcium ChannelsMagnesiumTRPV Cation ChannelsAnimalsBinding SitesCalcium SignalingCryoelectron MicroscopyHEK293 CellsHumansMolecular Dynamics SimulationMutagenesisPatch-Clamp TechniquesSf9 CellsSpodopteraCalcium Channel BlockersCalcium ChannelsMagnesiumTRPV6 protein, humanTRPV Cation Channels

Identifiers

PMID41198662
PMCPMC12592368

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.