ArticleZeitschrift fur medizinische Physik2026
Delayed convergence of iterative reconstruction in dopamine transporter SPECT with multiple-pinhole collimators.
Article in Zeitschrift fur medizinische Physik, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- From photons and their detectors, ultra short and "longer" times to tiny and giant PETs, golden eyes, AI and surgical probes - Nuclear Medicine has it all.Zeitschrift fur medizinische Physik · 2026Article
- Allometry correction in semi-quantitative analysis of dopamine transporter SPECT.EJNMMI research · 2025Article
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10 authors.
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Abstract
backgroundMultiple-pinhole (MPH) collimators for brain SPECT improve the resolution-sensitivity tradeoff compared with conventional parallel-hole and fan-beam collimators. The system count sensitivity profile with MPH collimators exhibits a peak at the center of the field-of-view and significant decline in count sensitivity toward the periphery. In MPH SPECT with [
methods671 patients (43.8% females, 67.3±11.3y) were included retrospectively. Projection data were acquired with a triple-head camera (Mediso AnyScan Trio) equipped with 2
resultsIterative reconstruction converged much slower in the extrastriatal reference region than in the striatum and its subregions. Considerable improvement of spatial resolution with increasing iteration number came with an acceptable increase of statistical noise. The discriminative power of the putaminal SBR was highest with 300 effective iterations. There was a small but significant reduction of reader confidence and between-readers agreement with 300 compared to 24 iterations, particularly in normal cases (Likert 6-score 2.325 versus 2.468, p < 0.001).
conclusions300 iterations provide a good compromise between spatial resolution, robustness and diagnostic power of semi-quantitative SBR analyses on one side versus statistical noise and between-readers variability on the other side. In order to avoid relevant loss of between-readers stability, readers should be specifically trained for reading [
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