Observational studyThe European respiratory journal2026
Prognostic value of disease severity and mechanical ventilation intensity in acute respiratory distress syndrome: analysis of the LUNG SAFE cohort.
Observational study in The European respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Mechanical Power as a Predictor of Outcomes During Mechanical Ventilation in Coronavirus Disease 2019 (COVID-19): An Updated Systematic Review.Journal of clinical medicine · 2026Review
- Discrepancies between estimated and geometrically derived mechanical power in invasively ventilated patients - insights from a randomized clinical trial.Intensive care medicine experimental · 2026Article
- Impact of Baydur ratio correction on the reliability of esophageal pressure measurement.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- The "respiratory envelope", an aviation-inspired framework for patient tailored mechanical ventilation.Critical care (London, England) · 2026Review
- Characterizing heterogeneity and subphenotyping acute respiratory distress syndrome with computed tomography.Intensive care medicine experimental · 2026Review
- Early trajectories of pulmonary hemodynamics in ARDS patients undergoing V-V ECMO: key determinants and prognostic impact.Critical care (London, England) · 2026Observational
- Lung recruitability determines the impact of PEEP on mechanical power in ARDS.Critical care (London, England) · 2026Article
- Dead space in critical care: a practical approach with clinical scenarios.Journal of anesthesia, analgesia and critical care · 2026Review
- Pulmonary vascular dysfunction in ARDS Pathophysiology and therapeutic implications.Annals of intensive care · 2026Review
- Beyond the PaOAnnals of intensive care · 2026Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to assess the prognostic performance of different indexes of oxygenation, respiratory mechanics and ventilation intensity in predicting 90-day mortality, and to estimate their independent associations, in a "real-world" observational cohort of acute respiratory distress syndrome (ARDS) patients on intensive care unit (ICU) mortality.
methodsThis is a secondary analysis of LUNG SAFE (Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE), an international prospective cohort study of patients with severe respiratory failure involving 459 ICUs from 50 countries. We evaluated the prognostic performance of oxygenation (arterial oxygen tension (
resultsAmong 2813 early ARDS patients, 516 (18.3%) met the inclusion criteria: mean±sd age 60±16 years, 61% male. Normalised elastance,
conclusionsNormalised elastance, DP and 4DP+RR, measured at day 1 of ARDS, were the best predictors of ICU mortality, and outperformed oxygenation and MP. DP showed the best balance between predictive accuracy and clinical simplicity. These results reinforce the importance of focusing on DP and 4DP+RR as key metrics to guide lung-protective strategies and ARDS severity classification.
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