Evidence map›Paper›PMID 41198189›Full record

Observational studyBMJ open respiratory research2025

Supine hyperinflation and expiratory flow limitation are associated with respiratory arousals and nocturnal hypoventilation in COPD.

Meera Srinivasan, David Touma, Kaj E C Blokland, Kieran Patel, Katrina O Tonga, David G Chapman, Andrew S L Chan, Peter A Cistulli, Gregory G King

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Meera SrinivasanDepartment of Respiratory and Sleep Medicine, Royal North Shore Hospital, St Leonards, New South Wales, Australia meera.srinivasan@act.gov.au.ORCID http://orcid.org/0000-0002-3646-0952
David ToumaDepartment of Respiratory and Sleep Medicine, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Kaj E C BloklandDepartment of Respiratory and Sleep Medicine, Royal North Shore Hospital, St Leonards, New South Wales, Australia.ORCID http://orcid.org/0000-0002-1807-6359
Kieran PatelDepartment of Respiratory and Sleep Medicine, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Katrina O TongaAirways Physiology and Imaging Group, Woolcock Institute of Medical Research, Macquarie University, Sydney, New South Wales, Australia.
David G ChapmanDepartment of Respiratory and Sleep Medicine, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Andrew S L ChanDepartment of Respiratory and Sleep Medicine, Royal North Shore Hospital, St Leonards, New South Wales, Australia.ORCID http://orcid.org/0000-0003-2559-3706
Peter A CistulliDepartment of Respiratory and Sleep Medicine, Royal North Shore Hospital, St Leonards, New South Wales, Australia.ORCID http://orcid.org/0000-0002-7920-4924
Gregory G KingDepartment of Respiratory and Sleep Medicine, Royal North Shore Hospital, St Leonards, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSubjective sleep disturbance is common in chronic obstructive pulmonary disease (COPD) and is related to hyperinflation when supine and tidal expiratory flow limitation (EFL). We hypothesised that abnormalities in supine lung mechanics disturb sleep and impair gas exchange in COPD. We aimed to assess relationships between supine lung derecruitment, EFL and hyperinflation, and polysomnographic measures of sleep disturbance and gas exchange in COPD.

methodsIn this prospective, observational study, supine oscillometry was performed in stable COPD patients to assess lung derecruitment (reactance at 5 Hz (Xrs

results28 COPD patients were enrolled (13 female, mean age (SD) 67.5 (8.71) years and mean forced expiratory volume in 1second (FEV1) z-scores (SD) -2.61 (1.06)). Worse Xrs

conclusionLung derecruitment, EFL and supine hyperinflation likely contribute to sleep disturbance and sleep-related gas exchange impairment in COPD.

Indexed as

ArousalHypoventilationPulmonary Disease, Chronic ObstructiveAgedExhalationFemaleHumansInspiratory CapacityMaleMiddle AgedPolysomnographyProspective StudiesPulmonary Gas ExchangeRespiratory MechanicsSupine PositionCOPD PathologyPulmonary Disease, Chronic ObstructiveRespiratory Measurement

Identifiers

PMID41198189
PMCPMC12593496

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.