SynthesisBrain stimulation
Evidence for safety and tolerability of transcranial magnetic stimulation for substance use disorders.
Synthesis in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Transcranial magnetic stimulation in cocaine use disorder and the risk of seizure: a review of the evidence.Frontiers in psychiatry · 2026Review
- Network-targeted TMS modulates nicotine craving and default mode network connectivity in psychotic disorders.Brain stimulationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
objectiveTranscranial magnetic stimulation (TMS) is an exciting novel treatment for substance use disorders (SUDs). While TMS is safe and effective in the general population, there have been concerns about its safety with concurrent substance use. To date, guidelines on managing substance use during TMS have been vague - recommending caution and weighing risks and benefits - and solely based on expert opinion, rather than based on quantitative data on the prevalence of TMS side effects with concurrent substance use.
methodsWe performed a systematic review with meta-analysis of TMS studies for a SUD - a clinically impairing level of substance use where we would be more likely to detect adverse effects - to quantify the safety of TMS in the setting of substance use. We searched PubMed, Embase, PsycINFO, and the Cochrane Library for TMS studies for SUDs that reported adverse effects. We extracted adverse effects and tested the difference between the prevalence of events in the active and sham conditions.
resultsForty-seven studies comprising 2865 participants with a SUD were included. The prevalence of neck pain and cognitive impairment was higher for sham compared to active TMS (p < .05). The prevalence of all other adverse effects, including seizure, was not significantly different between active and sham TMS.
conclusionsTMS is safe and well-tolerated for people with SUDs. The prevalence of side effects from TMS in people with SUDs is comparable to that in the general population. TMS can be just as safely administered for SUDs as for any other psychiatric disorder.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.