Chemical and biological characterization of glycidamide-adducted adenine in DNA.

Jun-Ichi Akagi, Ryota Yamaguchi, Yumi Miyake, Masayuki Yokoi, Kaoru Sugasawa, Shigenori Iwai

Abstract read

In one paragraph

Article in The Journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jun-Ichi AkagiDivision of Pathology, National Institute of Health Sciences, Kawasaki, Kanagawa, Japan. Electronic address: jun@nihs.go.jp.

Ryota YamaguchiDivision of Chemistry, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, Japan.

Yumi MiyakeForefront Research Center, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan; Core Facility Center, Osaka University, Toyonaka, Osaka, Japan.

Masayuki YokoiBiosignal Research Center, Kobe University, Kobe, Hyogo, Japan.

Kaoru SugasawaBiosignal Research Center, Kobe University, Kobe, Hyogo, Japan.

Shigenori IwaiDivision of Chemistry, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, Japan; Biosignal Research Center, Kobe University, Kobe, Hyogo, Japan; Frontiers of Innovative Research in Science and Technology, Konan University, Kobe, Hyogo, Japan. Electronic address: iwai.s.es@osaka-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acrylamide, a food contaminant, is metabolically converted to glycidamide (GA), which reacts with nucleobases in DNA. Although several GA adducts with dG, 2'-deoxyadenosine (dA), and dC are known, the mutagenic potency of each adduct remains unclear. Here, we focused on N

Indexed as

AdenineDeoxyadenosinesDNA AdductsEpoxy CompoundsMutagensCell Line, TransformedFood ContaminationHumansLiquid Chromatography-Mass Spectrometry2'-deoxyadenosineAdenineDeoxyadenosinesDNA AdductsEpoxy CompoundsglycidamideMutagensacrylamideDNA lesionDNA replicationglycidamidemutagenesisN(6)-adducted adeninenucleic acid chemistry

Identifiers

PMID41197734

DOI10.1016/j.jbc.2025.110898

PMCPMC12769786

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.