Evidence map›Paper›PMID 41197629›Full record

ArticleCell metabolism2025

12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.

Luiz Osório Leiria, Chih-Hao Wang, Matthew D Lynes, Kunyan Yang, Farnaz Shamsi, Mari Sato, Satoru Sugimoto, Emily Y Chen, Valerie Bussberg, Niven R Narain and 17 more

Abstract readPublished Erratum
In one paragraph

Article in Cell metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Targeting the cGAS-STING pathway mitigates Huntington disease pathogenesis in a knock-in mouse model.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Luiz Osório Leiria
Chih-Hao Wang
Matthew D Lynes
Kunyan Yang
Farnaz Shamsi
Mari Sato
Satoru Sugimoto
Emily Y Chen
Valerie Bussberg
Niven R Narain
Brian E Sansbury
Justin Darcy
Tian Lian Huang
Sean D Kodani
Masaji Sakaguchi
Andréa L Rocha
Tim J Schulz
Alexander Bartelt
Gökhan S Hotamisligil
Michael F Hirshman
Klaus van Leyen
Laurie J Goodyear
Matthias Blüher
Aaron M Cypess
Michael A Kiebish
Matthew Spite
Yu-Hua Tseng

Funding

Role of BMPs in Adipogenesis, Mitochondrial Function and Energy MetabolismR01DK077097 · NIDDK · JOSLIN DIABETES CENTER · PI TSENG, YU-HUA · 2007 to 2019
$5.6M
Fibroblast Growth Factor and Energy MetabolismR01DK102898 · NIDDK · JOSLIN DIABETES CENTER · PI TSENG, YU-HUA · 2015 to 2024
$4.1M
NIDDK NIH HHS R01 DK077097NIDDK NIH HHS R01 DK102898
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41197629
PMCPMC12707194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.