ReviewInternational dental journal2026
Proteomics of Periodontitis-Associated Bacteria and Its Link to Oral Squamous Cell Carcinoma: A Contemporaneous Review.
Review in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- In Reply to Yeong SK et al: 'Proteomics of Periodontitis Associated Bacteria'.International dental journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
INTRODUCTION AND
aimsPeriodontitis, a chronic inflammatory disease of the periodontium, causes gingival inflammation and bone loss. Meanwhile, oral cancer synonymously known as oral squamous cell carcinoma is characterised by uncontrolled cell growth in the oral cavity. Both conditions can compromise oral function and reduce quality of life. Oral bacteria are implicated in the link between periodontitis and oral squamous cell carcinoma, but the specific molecular alterations and pathways involved in carcinogenesis are yet to be elucidated. Hence, this review aimed to explore the role of proteomes of known oral bacteria in carcinogenesis at the molecular level.
methodsRelevant articles were searched through electronic databases at MEDLINE/Pubmed, EBSCOHost and Web of Science from 2017 to 2025.
resultsThree periodontal pathogens, Porphyromonas gingivalis, Fusobacterium nucleatum and Treponema denticola, are involved in cancer development. They express lipopolysaccharide, gingipain, FimA, mfa1, outer membrane vesicles, nucleoside disphosphate kinase, FadA and Treponema denticola chymotrypsin-like protease. They cause cancer via 5 different mechanisms: inflammation, inhibition of apoptosis, production of carcinogenic substances, cellular proliferation and cellular invasion. These occur alongside their ability to evade and escape host immune responses.
conclusionPeriodontitis and oral squamous cell carcinoma are linked through periodontal pathogens, which express various proteins. This highlights the importance of maintaining periodontal health to reduce the risk of oral squamous cell carcinoma and improve disease outcomes. CLINICAL RELEVANCE: Understanding how periodontal pathogens contribute to oral squamous cell carcinoma reinforces the need for early diagnosis and effective management of periodontitis. The identified bacterial proteins can serve as early diagnostic biomarkers for oral squamous cell carcinoma. Furthermore, clinicians should consider periodontal health not only for preserving dentition but also as part of cancer prevention strategies.
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Registered trials
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