Evidence map›Paper›PMID 41197228›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2025

An antifentanyl monoclonal antibody reverses fentanyl-induced apnea in pigs.

Carly Baehr, Eduardo Hatschbach, Jennifer Vigliaturo, Dustin Hicks, Sujata Pandit, Marcellene Hollingsworth, Heather Green, Derrick Hau, Elaine Gay, Ann M Decker and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Carly BaehrDepartment of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota. Electronic address: cbaehr@umn.edu.
Eduardo HatschbachDepartment of Veterinary Clinical Sciences, University of Minnesota College of Veterinary Medicine, St Paul, Minnesota.
Jennifer VigliaturoDepartment of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota.
Dustin HicksDepartment of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota.
Sujata PanditDepartment of Microbiology and Immunology, University of Nevada Reno School of Medicine, Reno, Nevada.
Marcellene HollingsworthDepartment of Microbiology and Immunology, University of Nevada Reno School of Medicine, Reno, Nevada.
Heather GreenDepartment of Microbiology and Immunology, University of Nevada Reno School of Medicine, Reno, Nevada.
Derrick HauDepartment of Microbiology and Immunology, University of Nevada Reno School of Medicine, Reno, Nevada.
Elaine GayCenter for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina.
Ann M DeckerCenter for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina.
Brooke HoppeDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington.
Aaron KhaimrajDepartment of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota.
David AucoinDepartment of Microbiology and Immunology, University of Nevada Reno School of Medicine, Reno, Nevada.
Scott P RunyonCenter for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina.
Alonso G P GuedesDepartment of Veterinary Clinical Sciences, University of Minnesota College of Veterinary Medicine, St Paul, Minnesota.
Marco PravetoniDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington; Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington; Garvey Institute for Brain Health Solutions, University of Washington School of Medicine, Seattle, Washington.

Funding

Development of a monoclonal antibody to reverse overdose from fentanyl and its analogs: from manufacturing to clinical trialsUG3DA057850 · NIDA · UNIVERSITY OF WASHINGTON · PI COMER, SANDRA D, PRAVETONI, MARCO · 2022 to 2022
$8.3M
Development of a monoclonal antibody to reverse overdose from fentanyl and its analogs: from manufacturing to clinical trialsUH3DA057850 · NIDA · UNIVERSITY OF WASHINGTON · PI SANDRA D. COMER, Marco Pravetoni · 2025 to 2026
$7.0M
Antibody-based countermeasures against fentanyl and its analoguesU01DA051658 · NIDA · UNIVERSITY OF WASHINGTON · PI PRAVETONI, MARCO · 2020 to 2022
$2.4M
NIDA NIH HHS U01 DA051658NIDA NIH HHS UG3 DA057850NIDA NIH HHS UH3 DA057850
6 · The paper itself

Abstract

The incidence of fatal drug overdoses has increased dramatically over the past decade due to the widespread availability of fentanyl and its analogs. As a complementary strategy to current overdose reversal agents, monoclonal antibodies (mAbs) are in development as therapeutics for prevention and reversal of fentanyl overdose. In the present study, the anti-fentanyl mAb HY6-F9 was tested for reversal of fentanyl-induced respiratory arrest (apnea) in a porcine model. In a first study, following fentanyl-induced apnea, chimeric HY6-F9 and naloxone control were administered as an intravenous bolus. Both chimeric HY6-F9 and naloxone restored spontaneous breathing within 90 seconds. Treatment with mAb increased the concentration of fentanyl in serum by 10-fold within the first minute after mAb bolus administration. In a second study, after induction of apnea, humanized HY6-F9 and naloxone control were administered as a slow intravenous infusion over 10 minutes to determine the ED

Indexed as

Analgesics, OpioidAntibodies, MonoclonalApneaFentanylAnimalsFemaleHumansNaloxoneNarcotic AntagonistsSwineAnalgesics, OpioidAntibodies, MonoclonalFentanylNaloxoneNarcotic AntagonistsFentanylMonoclonal antibodyOpioid use disorderOverdose

Identifiers

PMID41197228
PMCPMC13376824

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.