ArticleOrganic letters2025
Diazacyclobutene Ring Cleavage Provides 1,2-Diazetidin-3-ones via Intramolecular Nucleophilic Cyclization.
Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Reaction Products Revised and Mechanisms Revisited with Machine Learning-Augmented Computational NMR.The Journal of organic chemistry · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
We report an efficient two-step strategy for the synthesis of 1,2-diazetidin-3-ones (or aza-β-lactams) from thiolated diazacyclobutene intermediates. The transformation involves acid-promoted ring scission, followed by base-induced intramolecular nucleophilic cyclization, affording the desired diazetidinones in good yields. This method offers straightforward access to a structurally unique and underexplored four-membered heterocycle, expanding the synthetic toolbox for strained nitrogen-containing ring systems.
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Registered trials
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