ArticleScience (New York, N.Y.)2026
The origin of hepatocellular carcinoma depends on metabolic zonation.
Abstract read
In one paragraph
Article in Science (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Unraveling the tapestry: Lessons from multi-omics and spatial biology in hepatocellular cancer.Hepatology (Baltimore, Md.) · 2026Review
- Cuproptosis and ferroptosis: signal pathways, diseases and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- The Spatial Redox-Metalloptosis Axis in Liver Disease: A Hypothesis on Regional Susceptibility to Ferroptosis and Cuproptosis.Antioxidants (Basel, Switzerland) · 2026Review
- Alcohol reshapes liver zonal plasticity and immune-metabolic reprogramming in metabolic-syndrome associated hepatocellular carcinoma.Nature communications · 2026Article
- Adaptive oncogenesis of β-catenin emerges from declining liver tissue integrity.Nature communications · 2026Article
- Deciphering the Multiscale Morphology of Somatic Oncogenic Alterations in Hepatocellular Carcinoma.bioRxiv : the preprint server for biology · 2026Article
- GSTM3 Knockdown Promotes Liver Fibrosis Reversal by Inhibiting Hepatic Stellate Cell Activation via PPARγ Signaling.Journal of clinical and translational hepatology · 2026Article
- Late-stage dedifferentiation and epigenetic memory of cancer stem cells in hepatocellular carcinoma.Journal of translational medicine · 2026Article
- Liver endothelial zonation orchestrates hepatic steatosis onset through retinoic acid-regulated FGF1.Science advances · 2026Article
- Review
- Global Advances in Hepatocellular Carcinoma Research and Therapy in 2025.Cancer innovation · 2026Review
- Hot Zones for Liver Cancer: Metabolic Zonation, Ferroptosis, and the Origins of HCC.Cancer research · 2026Article
- Metabolic permissiveness: how tissue context shapes cancer.Genes & development · 2026Review
- Spatial immune dysregulation in MASLD: integration of lobular zoning, metabolism and immune function.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Jason Guo *Children's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-0062-5118
Roger Liang *Children's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Andrew Chung *Children's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-5273-1428
Zhijie Li *Children's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0009-0003-9610-0953
Boyuan LiChildren's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-9549-9884
Eric ChenChildren's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-9772-2357
Lin LiChildren's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-8715-7980
Jingjing WangChildren's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Meng-Hsiung HsiehChildren's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-9791-1318
Ivy Xiangyi FangChildren's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-9024-4281
Benjamin KrogerDepartment of Internal Medicine, Division of Hematology-Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-5675-9102
Yunguan WangChildren's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-0767-6188
Min ZhuChildren's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Xiongzhao RenChildren's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Greg ManninoChildren's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-4268-2260
Yuemeng JiaChildren's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-8019-1534
Yonglong WeiChildren's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-6152-7963
Stephen MooreChildren's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-4156-5350
Daniel J SiegwartDepartment of Biomedical Engineering, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-3823-1931
Stephen S ChungDepartment of Internal Medicine, Division of Hematology-Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-1433-7419
Zixi WangChildren's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-9354-1206
Tripti SharmaChildren's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-1799-1157
Suman KomjetiChildren's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yi HanQuantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-2835-9280
Purva GopalSimmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-7125-695X
Guanghua XiaoQuantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-9387-9883
Tao WangQuantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-4355-149X
Hao ZhuChildren's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-8417-9698
Funding
UT Southwestern Liver Cancer SPOREP50CA295495 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Yujin Hoshida, Amit Singal · 2025 to 2026
$7.5MUT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JOEL K. ELMQUIST · 2022 to 2026
$7.4MDefining the molecular interactions within nanoparticles that enable delivery of long nucleic acidsR01EB025192 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI SIEGWART, DANIEL JOHN · 2018 to 2025
$3.1MDetermining how chronic ETOH influences the regenerative activities of hepatocyte subpopulationsR01AA028791 · NIAAA · UT SOUTHWESTERN MEDICAL CENTER · PI ZHU, HAO · 2021 to 2025
$2.7MImproving hepatocellular carcinoma mouse modeling by understanding the malignant potential and biology of liver cell subpopulationsR01CA251928 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI ZHU, HAO · 2020 to 2024
$2.7MRegulation of Protein Synthesis in Leukemia Stem CellsR37CA273232 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Stephen Shiu-Wah Chung · 2023 to 2026
$1.9MMultiplexed nanoparticle delivery to increase CRISPR/Cas gene editing for enhanced cancer therapyR01CA269787 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Daniel John Siegwart · 2022 to 2026
$1.9MDeveloping computational algorithms for histopathological image analysisR01GM140012 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI XIAO, GUANGHUA · 2021 to 2024
$1.6MInformatics Tools To Analyze And Model Whole Slide Image Data At The Single Cell LevelU01CA249245 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI XIAO, GUANGHUA · 2021 to 2023
$1.5MInvestigating imitation SWI chromatin remodeling complexes in mammalian tissue regenerationR01DK125396 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ZHU, HAO · 2020 to 2023
$1.5MMachine learning for identifying antigen-antibody interactions from massive sequencing dataR01AI190103 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Junzhou Huang, JUN WANG · 2025 to 2026
$1.3MIntegrative Analysis to Identify Regulation Targets of RNA-Binding ProteinsR01GM115473 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI XIE, YANG · 2016 to 2019
$1.3MNCI NIH HHS P50 CA295495NCI NIH HHS R01 CA251928NCI NIH HHS R01 CA269787NCI NIH HHS R37 CA273232NCI NIH HHS U01 CA249245NHLBI NIH HHS F30 HL178281NIAAA NIH HHS R01 AA028791NIAID NIH HHS R01 AI190103NIAID NIH HHS R01 AI192499NIBIB NIH HHS R01 EB025192NIDDK NIH HHS F30 DK142444NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R01 DK125396NIGMS NIH HHS R01 GM115473NIGMS NIH HHS R01 GM140012
Abstract
The origin of cancer is poorly understood because premalignant cells are rarely followed in their native environments. Although the spatial compartmentalization of metabolic functions is critical for proper liver function, it is unknown whether cancers arise from some zones but not others and whether there are metabolic determinants of cancer risk. Zone-specific, mosaic introduction of
Indexed as
Carcinoma, HepatocellularLiver NeoplasmsAnimalsbeta CateninFerroptosisGlutathione TransferaseHumansLiverMiceMutationTranscription Factorsbeta CateninCTNNB1 protein, humanCTNNB1 protein, mouseGlutathione TransferaseTranscription Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.