ArticlePloS one2025
The effect of environmental stressors on anti-mullerian hormone levels in Lebanese women: a retrospective study.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundProlonged and repetitive exposure to stressors leads to detrimental effects on female reproductive health; this can consequently increase susceptibility to stress and elevate risk of adverse mental health outcomes. Since October 2019, Lebanon has been engulfed in a multipronged crisis, beginning with a severe economic collapse, which was further exacerbated by the COVID-19 pandemic, followed by the catastrophic Beirut Blast in August 2020. These compounding events caused considerable stress, resulting in a substantial mental health burden. We employed a retrospective approach to trace the trend in Anti-Mullerian Hormone levels (the most widely used measure of functional ovarian reserve) in a sample of reproductive-aged Lebanese women in a tertiary healthcare center in Beirut in light of the events described.
methodsA retrospective chart review was performed of women aged 18-40 with AMH levels tested between January 2018 and June 2023 [excluding the time period between February 2020 - December 2020] (n = 563). Patients who had AMH levels between January 2018 - January 2020 were included in the 'pre-stressful events' group (n = 254) while those tested between January 2021 - June 2023 were in the 'post-stressful events' group (n = 283). Patient's age, BMI, obstetrical and gynecological history, AMH level, and other relevant lab values were collected. Results were compared using the independent t-test.
resultsOverall, this study demonstrated a lower mean AMH level in the post-stressful events group as compared to the pre-stressful events group, but this difference was not statistically significant. Patients with PCOS had a significant decline in the mean AMH level, as did patients with primary infertility.
conclusionWomen with pre-existing reproductive health disorders, such as PCOS and infertility, are more vulnerable to stress and are more likely to experience a decline in AMH level and, by extension, ovarian reserve following stressful experiences.
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