Evidence map›Paper›PMID 41196854›Full record

ArticlePloS one2025

Depressive episode and treatment outcomes in elderly individuals with tuberculosis: A prospective cohort study in Korea.

Ahran Kim, Hyung Woo Kim, Ju Sang Kim, Jin Woo Kim, Yong Hyun Kim, Heayon Lee, Yeonhee Park, Jee Youn Oh, Hyeon-Kyoung Koo, Ock-Hwa Kim and 5 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ahran KimDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Hyung Woo KimDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Ju Sang KimDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Jin Woo KimDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Yong Hyun KimDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Heayon LeeDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Yeonhee ParkDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Jee Youn OhDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Hyeon-Kyoung KooDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea.
Ock-Hwa KimDivision of Pulmonology and Allergy, Department of Internal Medicine, Chungnam National University, Chungnam National University Sejong Hospital, Sejong, Republic of Korea.
Yun-Jeong JeongDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Republic of Korea.
Yong-Soo KwonDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
Won Yeon LeeDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Wonju Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
Yoolwon JeongDepartment of Preventive Medicine, Dankook University Hospital, Cheonan, Republic of Korea.
Jinsoo MinDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0001-6091-518X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDepression is common in the elderly and has been linked with poor tuberculosis treatment outcomes.

methodsWe conducted a prospective multicenter cohort study of adult aged ≥ 65 years with active tuberculosis in the Republic of Korea between 2020 and 2022. Sociodemographic and clinical data were obtained by interview. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9), with a score ≥10 indicating a depressive episode. Logistic regression analyses were conducted to identify factors associated with depressive episodes and evaluate their association with treatment outcomes.

resultsAmong the 361 elderly individuals with active tuberculosis who completed the questionnaire, 69 (19.1%) were classified as having a depressive episode. Depressive episodes were significantly associated with unemployment, higher comorbidity burden, and the presence of tuberculosis-related symptoms such as cough and constitutional symptoms. Functional impairment was reported in 39.6% (143/361) of all participants and increased with the greater severity of depressive symptoms. Suicidal ideation was observed in 19.7% (71/361) of all participants and was independently associated with alarming tuberculosis symptoms. Among the participants with rifampin-susceptible tuberculosis, those with depressive episodes had significantly lower treatment success rates (64.7% vs. 79.1%, p = 0.012). In multivariable logistic regression analysis, depression remained independently associated with reduced odds of treatment outcomes (adjusted odds ratio, 0.478; 95% confidence interval, 0.261-0.878).

conclusionsIn elderly individuals with tuberculosis, depressive episodes are associated with functional impairment, suicidal ideation, and poor treatment outcomes. Routine mental health assessments at tuberculosis diagnosis may help improve clinical outcomes in aging populations.

Indexed as

DepressionTuberculosisAgedAged, 80 and overAntitubercular AgentsFemaleHumansMaleProspective StudiesRepublic of KoreaSuicidal IdeationTreatment OutcomeAntitubercular Agents

Identifiers

PMID41196854
PMCPMC12591446

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.