Evidence map›Paper›PMID 41196691›Full record

ArticleACS nano2025

Intracompartmental 3D Printing of Enzymatically Active Organelle Mimics.

Yiğitcan Sümbelli, Anna C Jäkel, Madelief A M Verwiel, Nadia A Erkamp, Alexander F Mason, Friedrich C Simmel, Jan C M van Hest, Alexander B Cook

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yiğitcan SümbelliDepartment of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven 5600 MB, Netherlands.ORCID 0000-0002-5917-9581
Anna C JäkelPhysics of Synthetic Biological Systems, Department of Bioscience, School of Natural Sciences, Technical University of Munich, Garching 85748, Germany.ORCID 0000-0001-5041-0145
Madelief A M VerwielDepartment of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven 5600 MB, Netherlands.ORCID 0000-0002-4445-937X
Nadia A ErkampDepartment of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven 5600 MB, Netherlands.
Alexander F MasonSchool of Science, Molecular Horizons, University of Wollongong, Wollongong, New South Wales 2522, Australia.
Friedrich C SimmelPhysics of Synthetic Biological Systems, Department of Bioscience, School of Natural Sciences, Technical University of Munich, Garching 85748, Germany.ORCID 0000-0003-3829-3446
Jan C M van HestDepartment of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven 5600 MB, Netherlands.ORCID 0000-0001-7973-2404
Alexander B CookDepartment of Chemical Engineering and Chemistry, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven 5600 MB, Netherlands.ORCID 0000-0002-5005-1039

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introducing subcellular structures in artificial cells is a key step in mimicking the structure and role of organelles, which are instrumental in compartmentalizing cellular reaction networks. Despite the variety of strategies to include subcellular features within artificial cell models, achieving spatial and morphological control over these compartments remains challenging. In this study, we engineered 3D-printed subcellular compartments within terpolymer-stabilized coacervate-based artificial cells. Coacervate-forming charged polymers were functionalized with methacrylate moieties, enabling the fabrication of a variety of architectures within droplets through photoinitiated radical polymerization. The addition of a Ni-NTA functional methacrylate monomer to the coacervates led to its sequestration upon polymerization in these subcellular regions. As a result, the compartments were able to uptake and concentrate His

Indexed as

Artificial CellsOrganellesPrinting, Three-Dimensionalbeta-GalactosidaseMethacrylatesPolymerizationPolymersbeta-GalactosidaseMethacrylatesPolymers3D printingartificial cellartificial organellecoacervatecompartmentalizationphotopolymerization

Identifiers

PMID41196691
PMCPMC12632173

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.