Evidence map›Paper›PMID 41196513›Full record

ArticleNeuroscience bulletin2026

Oligodendrocyte Egr2 Mediates the Beneficial Effect of Resocialization on the Social Ability of Socially Isolated Mice.

Yanli Zhang, Sijia Chen, Shuying Zhang, Yue Li, Yimiao Wang, Min Cao, Yuxi Jin, Ze Wang, Shixin Ding, Ming Xiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yanli Zhang *Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, 211166, China. yanlizhang0229@njmu.edu.cn.ORCID http://orcid.org/0000-0001-8173-2024
Sijia Chen *Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, 211166, China.
Shuying ZhangJiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, 211166, China.
Yue LiJiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, 211166, China.
Yimiao WangJiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, 211166, China.
Min CaoJiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, 211166, China.
Yuxi JinJiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, 211166, China.
Ze WangJiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, 211166, China.
Shixin DingJiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, 211166, China. dingshixin0609@126.com.ORCID http://orcid.org/0000-0001-8224-4735
Ming XiaoJiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, 211166, China. mingx@njmu.edu.cn.ORCID http://orcid.org/0000-0001-5528-9102

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early social isolation (SI) impairs social ability, which can be partially rescued after resocialization, but the underlying mechanisms have been rarely addressed. This study reported that adolescent SI mice resocialized with group housing (GH) mice, but not with SI mice, showed improved social behavior performances, increased myelination in the medial prefrontal cortex (mPFC), and upregulated Egr2 expression in oligodendrocytes (OLs). Specific down-regulation of OL Egr2 in GH companions or overexpression of OL Egr2 in SI peers abolished or rescued their repair effects on mPFC hypomyelination and social ability defects in SI mice, respectively. Furthermore, the improving effect of GH companions on OL Egr2 expression and myelinogenesis in the mPFC of SI mice was abolished when GH mice were treated with corticosterone. RNA-sequencing analysis showed that Egr2 enhanced myelination by inhibiting PDGFRα. Together, these results revealed that the Egr2/PDGFRα axis mediates distinct peer effects in rescuing SI-induced hypomyelination and social ability impairment.

Indexed as

Early Growth Response Protein 2OligodendrogliaSocial BehaviorSocial IsolationAnimalsMaleMiceMice, Inbred C57BLMyelin SheathPrefrontal CortexEarly Growth Response Protein 2Egr2 protein, mouseEarly social isolationMedial prefrontal cortexMyelin plasticityResocializationSocial ability

Identifiers

PMID41196513
PMCPMC13221552

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.