Evidence map›Paper›PMID 41196488›Full record

ArticleAnnals of biomedical engineering2026

Biomechanical Characterization of Central Corneal Region Using Inflation Test and its Application to Predicting Central Corneal Response Under Intraocular Pressure.

Zimeng Zhou, Honghao Wang, Ying Zhang, Haijun Lv, Zhuoyu Zhang, Huaming Li, Xiuli Liu, Tingwei Quan, Xiaohua Lv, Shaoqun Zeng

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Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Zimeng Zhou *Britton Chance Center and MoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Honghao Wang *Britton Chance Center and MoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, Hubei, China. wanghonghao@hust.edu.cn.ORCID http://orcid.org/0000-0002-1622-0417
Ying ZhangBritton Chance Center and MoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Haijun LvBritton Chance Center and MoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Zhuoyu ZhangBritton Chance Center and MoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Huaming LiBritton Chance Center and MoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Xiuli LiuBritton Chance Center and MoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Tingwei QuanBritton Chance Center and MoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Xiaohua LvBritton Chance Center and MoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, Hubei, China. xhlv@hust.edu.cn.ORCID http://orcid.org/0000-0002-6266-5142
Shaoqun ZengBritton Chance Center and MoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Funding

National Key Research and Development Program of China 2022YFC2404500National Natural Science Foundation of China 62275094Postdoctoral Elite Talent Introduction Program of Hubei Province 2024HBBHJD030
6 · The paper itself

Abstract

objectiveTo determine the biomechanical properties of the central corneal region under intraocular pressure (IOP) and to develop an accurate method for predicting the corresponding responses.

methodsIn the rabbit corneal inflation test, a calculation method for the biomechanical properties in the thickness direction of the cornea was proposed. The corresponding stress-strain relationship was obtained from the change in the central corneal thickness and IOP. Finite element analysis (FEA) was utilized to predict the biomechanical responses of the central corneal region under IOP using the derived stress-strain relationship. The FEA predictions using the stress-strain relationships derived from the uniaxial tensile test and optical coherence elastography (OCE) were also conducted for comparison.

resultsThe prediction accuracy of the FEA based on the inflation test was evaluated against OCE (in-plane), OCE (out-of-plane), and uniaxial tensile test. Compared to these methods, the maximum deviation of the apex displacement prediction based on the inflation test decreased by 73.2, 88.4, and 64.4%, respectively, and the maximum deviation of the central curvature prediction decreased by 89.2, 30.7, and 49.7%, respectively.

conclusionThe stress-strain relationship in the thickness direction of the cornea can provide the most accurate prediction result of the corneal biomechanical responses under IOP. The inflation test-based method proposed can serve as an accurate tool for biomechanical characterization of the central corneal region.

Indexed as

CorneaIntraocular PressureModels, BiologicalAnimalsBiomechanical PhenomenaFinite Element AnalysisRabbitsStress, MechanicalCorneal biomechanical characterizationFinite element analysis (FEA)Inflation testIntraocular pressureOptical coherence elastography (OCE)Uniaxial tensile test

Identifiers

PMID41196488

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.