ArticleBulletin of experimental biology and medicine2025
Modifications of the Secretome of Mesenchymal Stromal Cells under Conditions of Stress-Induced Aging.
Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Stress-Induced Senescence of Human Umbilical Cord Mesenchymal Stromal Cells Caused by Mitomycin C.Bulletin of experimental biology and medicine · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is known that the senescence-associated secretory phenotype (SASP) can promote senescence of surrounding normal cells. However, SASP signaling during senescence of mesenchymal stromal cells (MSCs) has not yet been fully studied. We determined the pattern of secreted proteins specific to MSCs under stress-induced senescence. Using chromatography-mass spectrometry, proteins specific to the secretome of senescent or "young" cells were identified. The secretome of senescent cells contains proteins both associated with senescence (LOXL2, CCL2, PLAT, SERPINE2, etc.) and important for reducing the impact of these processes, in particular, proteins responsible for inhibition of oxidative stress (MIF, PRDX5, GSTM2), detoxification of methylglyoxal (GLO1), and suppression of inflammatory reactions (GAS6, GSTM2). The obtained results indicate the complex etiology of aging and the ambiguity of the function of SASP within the paracrine induction of aging of neighboring cells.
Indexed as
Identifiers
41196481What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.