Evidence map›Paper›PMID 41196397›Full record

Trial reportClinical oral investigations2025

Regular home use of dual-light photodynamic therapy as an adjunct to non-surgical periodontal treatment in smokers: a single-center randomized controlled clinical trial.

Chrysoula Vakaki, Ioannis Fragkioudakis, Tommi Pätilä, Dimitra Sakellari

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05962801 (Regular Home Use of Dual-light Photodynamic Therapy as an Adjunct to Non-surgical Periodontal Treatment in Smokers), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05962801 naunknown statusnot on this map

Regular Home Use of Dual-light Photodynamic Therapy as an Adjunct to Non-surgical Periodontal Treatment in Smokers

TypeinterventionalSponsorAristotle University Of ThessalonikiRan2023 to 2024Enrolled60ConditionsPeriodontitis, Dual- Light Photodynamic Therapy, Smoking, Cigarette, Non-surgical Periodontal TherapyArmsLumoral device, Lumorinse
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chrysoula VakakiDepartment of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Ioannis FragkioudakisDepartment of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece. ifragkio@dent.auth.gr.
Tommi PätiläMetropolia University of Applied Sciences, Helsinki, Finland.
Dimitra SakellariDepartment of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis RCT assessed the effectiveness of daily home-applied dual-light antimicrobial photodynamic therapy (aPDT) as an adjunct to non-surgical periodontal therapy (NSPT) in smokers with Stage III or IV periodontitis. MATERIALS AND

methodsSixty smokers were randomized to receive either NSPT alone (control) or NSPT with daily for four months at-home application of aPDT, prior to oral hygiene (test group). Clinical parameters-bleeding on probing (BoP), probing depth (PD), clinical attachment loss (CAL), gingival recession (REC), full-mouth plaque score (FMPS), and Turesky Index-were assessed at baseline, 2 weeks, 4 months, and 6 months. aMMP-8 levels and patient-reported outcomes were also recorded.

resultsBoth groups demonstrated significant improvements in BoP, PD, and CAL (p < 0.05), but no significant intergroup differences were observed. BoP reduction at 2 weeks favored the test group (- 33.60% vs - 23.94%; p = 0.056). BoP continued to decrease at 4 and 6 months, reaching 29.55 ± 19.86% in the control group and 27.57 ± 16.43% in the test group at 6 months. The difference in mean BoP between the two groups at 6 months was not statistically significant (p = 0.680, Independent Samples Mann Whitney U Test). Plaque indices and aMMP-8 levels showed no significant differences. Compliance to dual-light aPDT averaged 77.7%; 72% of test participants were compliant. Greater compliance correlated with statistically significant improvements in mean values of all clinical parameters, whereas non-compliant patients presented with no changes (Related samples Friedman's Two-Way Analysis). Patient-centered outcomes revealed positive feedback, with 84% of the patients willing to recommend the device and minor adverse effects.

conclusionIn smokers with advanced periodontitis, adjunctive home use of dual-light aPDT did not result in statistically significant improvements over NSPT alone in clinical parameters such as BoP, PD, or CAL. Future placebo-controlled, long-term clinical trials are warranted to further assess its potential role in supportive periodontal care. CLINICAL RELEVANCE: Within the limitations of this study, dual-light aPDT cannot be recommended as a superior adjunct to conventional treatment.

trial registrationClinicalTrials.gov Identifier: NCT05962801.

Indexed as

PeriodontitisPhotochemotherapySmokersAdultCombined Modality TherapyFemaleHumansMaleMiddle AgedOral HygienePeriodontal IndexPhotosensitizing AgentsTreatment OutcomePhotosensitizing AgentsAdjunctive TreatmentNon-surgical Periodontal TherapyPeriodontitisPhotodynamic TherapySmoking

Identifiers

PMID41196397
PMCPMC12592251

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.