ArticleCellular and molecular life sciences : CMLS2025
Small extracellular vesicles derived from human umbilical cord mesenchymal stem cells attenuate photoaging by modulating the GATA2/PZP/GRP75 axis.
Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Paeonol-Loaded Cyclodextrin/Composite Hydrogel for Enhanced Transdermal Delivery and Skin Photoaging Repair.Gels (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The skin is one of the earliest organs in the human body to exhibit signs of aging, with photoaging mainly caused by chronic ultraviolet (UV) exposure and recognized as a major form of extrinsic aging. Small extracellular vesicles derived from human umbilical cord mesenchymal stem cells (hucMSC-sEVs) have been shown to delay skin aging by upregulating pregnancy zone protein (PZP), which modulates inflammatory responses, oxidative stress, and extracellular matrix remodeling. However, the core regulatory network underlying these effects remains unclear. Focusing on PZP, this study integrated bioinformatics to identify GATA2 as a potential upstream transcriptional regulator and GRP75 as a possible downstream target, indicating a GATA2/PZP/GRP75 signaling axis that may regulate photoaging. ChIP assays and dual-luciferase reporter analyses confirmed that GATA2 binds to the promoter region of PZP and upregulates its transcription. Knockdown and overexpression experiments further demonstrated that GATA2 suppresses or promotes PZP expression, thereby significantly influencing the senescence phenotype of dermal fibroblasts under UV irradiation. In addition, protein docking, co-immunoprecipitation (CoIP), and immunofluorescence colocalization assays validated the interaction between PZP and GRP75. PZP alleviates mitochondrial calcium overload and dysfunction by inhibiting the abnormal elevation of GRP75, thus delaying photoaging. These findings offer novel insights and targets for skin-aging intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.