Evidence map›Paper›PMID 41196380›Full record

ArticleSurgery today2026

Survival benefit of lymph node dissection and prediction of lymph node metastasis in patients with intrahepatic cholangiocarcinoma.

Kyohei Yugawa, Shinji Itoh, Takuma Izumi, Takeo Toshima, Takashi Motomura, Sunao Fujiyoshi, Norifumi Iseda, Yuriko Tsutsui, Tomoharu Yoshizumi

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Kyohei YugawaDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Shinji ItohDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan. itoh.shinji.453@m.kyushu-u.ac.jp.
Takuma IzumiDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Takeo ToshimaDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Takashi MotomuraDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Sunao FujiyoshiDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Norifumi IsedaDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Yuriko TsutsuiDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Tomoharu YoshizumiDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.

Funding

JSPS KAKENHI grant 23K08133
6 · The paper itself

Abstract

purposeLymph node metastasis (LNM) is strongly associated with a poor survival in patients with intrahepatic cholangiocarcinoma (ICC). However, the indications for lymph node dissection (LND) are controversial. This study assessed the accuracy of preoperative imaging for detecting LNM.

methodsEighty-nine patients who underwent curative resection for ICC between 2001 and 2022 were enrolled and analyzed retrospectively. Lymph node status was evaluated preoperatively using contrast-enhanced computed tomography (CT) and positron emission tomography (PET)/CT. Patients were grouped according to their LND status (LND or no LND). Patients in the LND group were further grouped according to pathological LNM status (pN+, LNM-positive; and pN0, LNM-negative).

resultsAdequate LND was performed in 44 (49.4%) patients, among whom LNM was diagnosed in 17 (38.6%). The 3-year overall survival rates in patients with LND/pN+, LND/pN0, and no LND were 16.2%, 70.0%, and 70.7%, respectively. The corresponding 3-year recurrence-free survival rates were 11.8, 52.6, and 42.6%, respectively. A lymph node diameter > 8 mm on preoperative CT was an independent predictor of LNM. The maximum standardized uptake value (SUVmax) on PET/CT was significantly associated with LNM.

conclusionLymph node diameter and SUVmax predicted LNM in patients with resectable ICC. A preoperative lymph node evaluation can ensure optimal treatment outcomes.

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaLymphatic MetastasisLymph Node ExcisionAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedPositron Emission Tomography Computed TomographyRetrospective StudiesSurvival RateTomography, X-Ray ComputedIntrahepatic cholangiocarcinomaLymph node dissectionLymph node metastasisPET/CTPrognosis

Identifiers

PMID41196380

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.