Evidence map›Paper›PMID 41196302›Full record

ReviewInfection and immunity2025

Control of human Q fever by vaccination: the journey to Q-VAX and beyond.

Robert A Heinzen, Kathleen N Pierce, Daniel E Voth, John Stenos, Stephen Graves, Carrie Mae Long

Abstract readReviewHistorical Article
PubMed Full text at PMC Publisher
In one paragraph

Review in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Robert A HeinzenLaboratory of Bacteriology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, Montana, USA.ORCID 0000-0001-6870-4619
Kathleen N PierceLaboratory of Bacteriology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, Montana, USA.ORCID 0009-0003-2448-1822
Daniel E VothDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID 0000-0002-7631-7827
John StenosAustralian Rickettsial Reference Laboratory, Barwon Health, Geelong, Victoria, Australia.ORCID 0000-0001-5465-2926
Stephen GravesAustralian Rickettsial Reference Laboratory, Barwon Health, Geelong, Victoria, Australia.
Carrie Mae LongLaboratory of Bacteriology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, Montana, USA.ORCID 0000-0001-5030-975X

Funding

NHLBI NIH HHS
6 · The paper itself

Abstract

Current vaccine development efforts encompass diverse and innovative approaches; however, studies with basic vaccines (e.g., whole cell inactivated) continue to inform these efforts. Perhaps the world's most effective and durable human vaccine, the query (Q) fever vaccine known as Q-VAX, can trigger a severe post-vaccination hypersensitivity reaction, precluding its widespread deployment. The history of Q fever vaccine development serves as a rich example of the power of scientific collaboration, elegant experimentation, and the study of adverse post-vaccination events. Here, we review the history of Q fever vaccine development, profiling seminal studies while also relating this information to modern vaccine development efforts.

Indexed as

Bacterial VaccinesCoxiella burnetiiQ FeverVaccinationAnimalsHistory, 20th CenturyHistory, 21st CenturyHumansVaccine DevelopmentBacterial Vaccinesbacterial vaccineCoxiella burnetiihistoryhuman vaccinationQ feverQ-VAXvaccine

Identifiers

PMID41196302
PMCPMC12707119

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.