SynthesisSurgical endoscopy2025
Effects of NB2C on hernia repair, a systematic review and meta-analysis of randomized controlled trial.
Synthesis in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Glue versus absorbable tacks for mesh fixation in laparoscopic inguinal hernia repair: a systematic review and meta-analysis of postoperative pain and complications.Hernia : the journal of hernias and abdominal wall surgery · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn hernia repair, mesh fixation methods impact postoperative pain and recovery. While penetrating fixations such as tacks or sutures may cause chronic pain, non-penetrating alternatives such as n-butyl-2-cyanoacrylate (NB2C) glue remain under investigation.
methodsA meta-analysis of randomized controlled trials (RCTs) was conducted to compare NB2C with sutures or tacks in groin hernia repair. Databases searched included PubMed, Web of Science, Embase, Cochrane Library, and Scopus (up to April 28, 2025). Primary outcomes were postoperative pain (VAS) and operative time; secondary outcomes included complications and recurrence.
resultsSeven RCTs involving 1111 patients were included. Compared with sutures, NB2C was associated with reduced postoperative pain (MD - 0.72; 95% CI - 1.42 to - 0.02; p = 0.04) and shorter operative time (MD - 3.86 min; 95% CI - 5.27 to - 2.44; p < 0.01). No significant differences were observed between NB2C and tacks regarding pain or complications, nor between NB2C and sutures regarding complications and recurrence.
conclusionNB2C offers reduced pain and operative time compared to sutures but shows no clear advantage over tacks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.