Evidence map›Paper›PMID 41196282›Full record

Trial reportAntimicrobial agents and chemotherapy2025

Intrapulmonary penetration and pharmacokinetics of siderophore cephalosporin HRS-8427 injection in Chinese healthy subjects.

Yichen Cao, Yuanyuan Huang, Jinlian Xie, Qian Wu, Shuang Yang, Xiaoyan Yang, Jie Huang, Jinlong Liu, Jie Meng, Guoping Yang

Abstract readRandomized Controlled TrialClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yichen Cao *Clinical Pharmacology Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yuanyuan Huang *Jiangsu Hengrui Pharmaceuticals Co, Ltd, Shanghai, China.ORCID 0009-0003-5851-4856
Jinlian XieClinical Pharmacology Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Qian WuClinical Pharmacology Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Shuang YangClinical Pharmacology Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Xiaoyan YangClinical Pharmacology Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Jie HuangClinical Pharmacology Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID 0000-0002-1945-6353
Jinlong LiuXiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China.
Jie Meng *Department of Pulmonary and Critical Care Medicine, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Guoping Yang *Clinical Pharmacology Center, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID 0000-0001-5930-586X

Funding

Natural Science Foundation of Hunan Province 2023JJ60513
6 · The paper itself

Abstract

HRS-8427, a novel siderophore cephalosporin antibiotic, is under development for treating Gram-negative infections. This study evaluated the intrapulmonary penetration and pharmacokinetic (PK) profile of HRS-8427 injection following single and multiple dose administrations in healthy Chinese subjects. A single-center, randomized, open-label Phase 1 trial enrolled 38 subjects, with 35 completing the study. In the single-dose group, subjects received a 1,500 mg intravenous infusion of HRS-8427 over 2 h. In the multiple-dose group, subjects were administered 2,000 mg of HRS-8427 intravenously every 8 h for four consecutive doses, each infused over 2 h. Bronchoalveolar lavage (BAL) was conducted to collect epithelial lining fluid (ELF) and alveolar macrophage (AM) specimens. PK analysis demonstrated a maximum plasma concentration (

Indexed as

Anti-Bacterial AgentsCephalosporinsLungSiderophoresAdultArea Under CurveBronchoalveolar Lavage FluidEast Asian PeopleFemaleHealthy VolunteersHumansMacrophages, AlveolarMaleMiddle AgedYoung AdultAnti-Bacterial AgentsCephalosporinsSiderophoresbronchoalveolar lavageepithelial lining fluidHRS-8427intrapulmonary pharmacokinetic

Identifiers

PMID41196282
PMCPMC12691601

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.