ArticleAntimicrobial agents and chemotherapy2026
Variations in ventricular distribution of polymyxin B following intraventricular administration in patients with central nervous system infections.
Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Comparison of the Efficacy and Safety of Intravenous Ceftazidime-Avibactam and Intrathecal/Intraventricular Polymyxin B Sulfate in the Treatment of CNS Infections Caused by KPC-Antibiotics (Basel, Switzerland) · 2026Article
- Case Commentary: Intraventricular polymyxin B-small steps, big questions.Antimicrobial agents and chemotherapy · 2026Article
- From Laboratory to Clinic: Translational Medicine Paradigm of Polymyxin B Nanopreparations for Overcoming Drug-Resistant Bacterial Infections.International journal of nanomedicine · 2026Review
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10 authors.
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Abstract
Polymyxin B (PMB) demonstrates activity against multidrug-resistant Gram-negative pathogens. Intraventricular administration is considered when systemic therapy yields suboptimal cerebrospinal fluid (CSF) levels. We describe two cases of carbapenem-resistant gram-negative meningoencephalitis successfully treated with intraventricular PMB, in which unilateral PMB administration appeared to achieve bilateral ventricular distribution, with higher concentrations on the administration side. A potential association was observed between reduced CSF drainage and increased PMB concentrations. These findings may offer preliminary insights into optimizing PMB dosing strategies for CNS infections.
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