Evidence map›Paper›PMID 41196187›Full record

ArticlePhysiological genomics2026

Chamber-specific transcriptomic insight into cardiac development using guinea pig and human heart tissue.

Shatha Salameh, Devon Guerrelli, Luther M Swift, Anika Haski, Alisa Bruce, Manan Desai, Yves d'Udekem, Nikki Gillum Posnack

Abstract read
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In one paragraph

Article in Physiological genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shatha SalamehChildren's National Heart Center, Children's National Hospital, Washington, District of Columbia, United States.ORCID 0000-0001-9624-4277
Devon GuerrelliChildren's National Heart Center, Children's National Hospital, Washington, District of Columbia, United States.ORCID 0000-0003-0025-5997
Luther M SwiftChildren's National Heart Center, Children's National Hospital, Washington, District of Columbia, United States.ORCID 0000-0002-0050-1329
Anika HaskiChildren's National Heart Center, Children's National Hospital, Washington, District of Columbia, United States.
Alisa BruceChildren's National Heart Center, Children's National Hospital, Washington, District of Columbia, United States.
Manan DesaiChildren's National Heart Center, Children's National Hospital, Washington, District of Columbia, United States.
Yves d'UdekemChildren's National Heart Center, Children's National Hospital, Washington, District of Columbia, United States.ORCID 0000-0003-1851-7836
Nikki Gillum PosnackChildren's National Heart Center, Children's National Hospital, Washington, District of Columbia, United States.ORCID 0000-0002-3880-7200

Funding

Off-label drugs in cardiology: evaluating age- and disease-appropriate therapiesR01HD108839 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI Nikki Gillum Posnack · 2022 to 2026
$3.3M
Investigating age-dependent differences in cardiac drug responseF31HL172563 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI SALAMEH, SHATHA · 2024 to 2024
$35k
HHS | National Institutes of Health (NIH) F31HL172563HHS | National Institutes of Health (NIH) R01HD108839NHLBI NIH HHS F31 HL172563NICHD NIH HHS R01 HD108839
6 · The paper itself

Abstract

The heart undergoes significant molecular and functional adaptations throughout postnatal development. However, our understanding of these dynamic changes in the human heart is limited. Advances in pediatric cardiac research are often hindered by the lack of preclinical models. Guinea pigs may serve as a useful model for human cardiac research, as the guinea pig and human myocardium have similar ion channel expression and cardiovascular drug responsiveness. Yet, gene expression patterns during postnatal heart development have not been comprehensively investigated. In this study, we first characterized transcriptional changes in neonatal, juvenile, and adult guinea pig hearts. Neonatal hearts overexpressed cell-cycle (e.g.,

Indexed as

Gene Expression ProfilingHeart AtriaHeart VentriclesAnimalsBiomarkersGuinea PigsHeartHumansMitosisMyocytes, CardiacTime FactorsBiomarkerscardiac maturationguinea pighumanspediatricstranscriptomics

Identifiers

PMID41196187
PMCPMC12867090

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.