ArticleThe journal of physical chemistry letters2025
Protonation-Enhanced Energy Transfer in Xanthorhodopsin Kin4B8.
Article in The journal of physical chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Vibronic Reorganization Suppresses Salinixanthin-to-Retinal Energy Transfer in the Freshwater Kin4B8 Xanthorhodopsin.The journal of physical chemistry letters · 2026Article
- CaThe journal of physical chemistry letters · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial rhodopsins are key light-harvesting proteins for energy conversion in aquatic environments. While typically reliant on retinal, xanthorhodopsins (XRs) also employ carotenoids as antenna pigments. Here, we investigate Kin4B8, a novel freshwater XR that exhibits a counterintuitive increase in lutein-to-retinal excitation-energy transfer (EET) efficiency under acidic conditions─from 40% at neutral pH to 55%─despite a redshift in its absorption spectrum. By integrating spectroscopic measurements with quantum chemical calculations, we examine the influence of pH-dependent protonation states of two key residues, His60 and Asp94, on EET. We find that protonation of Asp94, in particular, markedly enhances lutein-retinal electronic coupling while moderately reducing spectral overlap. The 1.24-fold increase in squared coupling compensates for the decreased overlap, resulting in a net 1.07-fold increase in the EET rate. These findings suggest that rhodopsin-carotenoid complexes employ protonation-dependent tuning of carotenoid-retinal energy transfer as a mechanism for pH-responsive adaptation to diverse light environments.
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