ArticleAmerican journal of physiology. Cell physiology2026
Mucin 5ac modulates cancer-associated fibroblast heterogeneity through epigenetic reprogramming of precursor cells.
Rachel J Kehrberg, Namita Bhyravbhatla, Zahraa W Alsafwani, Xiaoqi Li, Gopalakrishnan Natarajan, Imran Khan, Randall E Brand, Maneesh Jain, Surinder K Batra, Sushil Kumar
Abstract read
In one paragraphArticle in American journal of physiology. Cell physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
10 authors.
Rachel J KehrbergDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States.ORCID 0009-0007-1754-4628 Namita BhyravbhatlaDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States.
Zahraa W AlsafwaniDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States.ORCID 0009-0006-1795-3598 Xiaoqi LiDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States.
Gopalakrishnan NatarajanDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States.
Imran KhanDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States.
Randall E BrandUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States.
Maneesh JainDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States.
Surinder K BatraDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States.ORCID 0000-0001-9470-9317 Sushil KumarDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States.ORCID 0000-0002-2155-3443 Funding
UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI James Eudy · 1985 to 2026
$55.0MValidation of biomarkers for risk prediction and early diagnosis of Pancreatic AdenocarcinomaU01CA200466 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Surinder K. Batra, Randall Brand · 2016 to 2026
$11.3MProject 3: MUC16-Mediated Metabolic Reprograming Induces PC MetastasisP01CA217798 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI THAYER, SARAH P · 2018 to 2022
$8.1MModulation of Tumor Microenvironment for Improved Therapy of Pancreatic CancerR01CA247471 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BATRA, SURINDER K., JAIN, MANEESH · 2020 to 2024
$2.8MRole of PD2/Paf1 in Pancreatic Acinar to Ductal MetaplasiaR01CA210637 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BATRA, SURINDER K., PONNUSAMY, MOORTHY P. · 2017 to 2021
$2.0MRac1 GTPase in tumorigenesis and progression of pancreatic cancerR01CA206444 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BATRA, SURINDER K., OUELLETTE, MICHEL M · 2016 to 2020
$1.9MTargeting LIF/LIFR in pancreatic cancerR44CA235991 · NCI · EVESTRA, INC. · PI KUMAR, SUSHIL, NAIR, HAREESH BABU · 2019 to 2021
$1.7MTargeting Mucin and EGFR Axis in Pancreatic CancerR01CA183459 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BATRA, SURINDER K. · 2014 to 2018
$1.6MHHS | NIH | NCI | Center for Cancer Research (CCR) PO1 CA217798HHS | NIH | NCI | Center for Cancer Research (CCR) RO1 CA183459HHS | NIH | NCI | Center for Cancer Research (CCR) RO1 CA206444HHS | NIH | NCI | Center for Cancer Research (CCR) RO1 CA210637HHS | NIH | NCI | Center for Cancer Research (CCR) UO1 CA200466NCI NIH HHS P01 CA217798NCI NIH HHS P30 CA036727NCI NIH HHS R01 CA183459NCI NIH HHS R01 CA206444NCI NIH HHS R01 CA210637NCI NIH HHS R01 CA247471NCI NIH HHS R44 CA235991NCI NIH HHS U01 CA200466
6 · The paper itselfAbstract
Pancreatic cancer (PC) is characterized by extensive desmoplasia, with heterogeneous cancer-associated fibroblasts (CAFs) as a major component. However, the contribution of distinct precursor cells to CAF heterogeneity remains poorly defined. This study investigated the role of Muc5ac in modulating CAF heterogeneity by maturing precursor cells, including adipose-derived mesenchymal stem cells (AD-MSCs), bone marrow-derived MSCs (BM-MSCs), and pancreatic stellate cells (PSCs), into different CAF subsets. RNA sequencing of precursor cells treated with conditioned media from Muc5ac-proficient or -deficient cancer cells revealed distinct transcriptional profiles. Muc5ac significantly modulated the expression of
Indexed as
Cancer-Associated FibroblastsCellular ReprogrammingEpigenesis, GeneticMesenchymal Stem CellsMucin 5ACPancreatic NeoplasmsAnimalsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMaleMicePancreatic Stellate CellsMUC5AC protein, humanMucin 5ACCAF heterogeneityepigeneticsMuc5acpancreatic cancerstroma
Identifiers
PMID41196138
PMCPMC13202592
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