Evidence map›Paper›PMID 41196119›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Odd-Chain Dicarboxylic Acid Feeding Produces a Glutaric Aciduria Type 1-Like Metabolic Signature in Mice.

Adam C Richert, Yuxun Zhang, Sivakama S Bharathi, Abigail Hernandez, Tetyana Dodatko, Joanna Bons, Kayla E Roundtree, Brandon Stauffer, Chunli Yu, Birgit Schilling and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Adam C RichertDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Yuxun ZhangDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Sivakama S BharathiDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Abigail HernandezDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Tetyana DodatkoDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Joanna BonsThe Buck Institute for Research on Aging, Novato, California, USA.
Kayla E RoundtreeDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Brandon StaufferDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Chunli YuDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Birgit SchillingThe Buck Institute for Research on Aging, Novato, California, USA.
Sander M HoutenDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID https://orcid.org/0000-0002-6167-9147
Eric S GoetzmanDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-9476-309X

Funding

Regulation of Peroxisomal Metabolism by Lysine AcylationR01DK090242 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GOETZMAN, ERIC S · 2011 to 2024
$5.4M
Allosteric regulation of lysine degradation as a novel pathophysiological mechanism in glutaric aciduria type 1R01HD112518 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert J DeVita, Sander Michel Houten · 2023 to 2026
$2.9M
MARC at the University of Missouri-ColumbiaT34GM136493 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI KING, ELIZABETH GRIEP, SCHULZ, DAVID J · 2020 to 2024
$2.0M
Optimizing medium-chain lipids for the treatment of long-chain fatty acid oxidation disordersR01HD103602 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GOETZMAN, ERIC S · 2021 to 2025
$1.7M
Targeting succinyl-CoA:glutarate-CoA transferase as a novel therapeutic strategy for glutaric aciduria type 1R01HD118270 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert J DeVita, Sander Michel Houten · 2025 to 2026
$1.5M
HHS | National Institutes of Health (NIH) DK090242HHS | National Institutes of Health (NIH) DK120531HHS | National Institutes of Health (NIH) HD103602HHS | National Institutes of Health (NIH) HD112518HHS | National Institutes of Health (NIH) HD118270HHS | National Institutes of Health (NIH) OD028654NICHD NIH HHS R01 HD103602NICHD NIH HHS R01 HD112518NICHD NIH HHS R01 HD118270NIDDK NIH HHS R01 DK090242NIGMS NIH HHS T34 GM136493
6 · The paper itself

Abstract

Glutaric aciduria type-1 (GA1) is an inherited mitochondrial neurometabolic disorder with a poorly understood pathogenesis and unmet medical needs. GA1 can be diagnosed via its hallmark biochemical signature consisting of glutaric aciduria, 3-hydroxyglutaric aciduria, and increased plasma glutarylcarnitine. These glutaryl-CoA-derived metabolites are thought to originate solely in the mitochondria. Here, we demonstrate that wild-type mice fed an 11-carbon odd-chain dicarboxylic acid (undecanedioic acid, DC

Indexed as

Amino Acid Metabolism, Inborn ErrorsBrain Diseases, MetabolicDicarboxylic AcidsGlutaryl-CoA DehydrogenaseAnimalsGlutaratesMaleMiceMice, Inbred C57BLMitochondriaPeroxisomesDicarboxylic AcidsGlutaratesglutaric acidGlutaryl-CoA Dehydrogenasedicarboxylic acidsglutaric acidemia Iglutaryl‐coenzyme Amitochondriaperoxisomessuccinyl‐coenzyme A

Identifiers

PMID41196119
PMCPMC13066932

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.