Evidence map›Paper›PMID 41196050›Full record

ArticlemSystems2025

Metagenome-assembled genomes reveal microbial signatures and metabolic pathways linked to coronary artery disease.

Soomin Lee, Shahbaz Raza, Eun-Ju Lee, Yoosoo Chang, Seungho Ryu, Hyung-Lae Kim, Si-Hyuck Kang, Han-Na Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Soomin LeeDepartment of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Republic of Korea.
Shahbaz RazaDepartment of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Republic of Korea.
Eun-Ju LeeDepartment of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Republic of Korea.
Yoosoo ChangDepartment of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Republic of Korea.
Seungho RyuDepartment of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Republic of Korea.ORCID 0000-0002-3927-8646
Hyung-Lae KimDepartment of Biochemistry, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.
Si-Hyuck KangCardiovascular Center, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea.
Han-Na KimDepartment of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Republic of Korea.ORCID 0000-0001-7053-7469

Funding

National Research Foundation of Korea RS-2023-NR077149
6 · The paper itself

Abstract

Gut microbiota has emerged as a critical factor influencing cardiovascular disease (CVD) risk, particularly coronary artery disease (CAD) development. Using fecal metagenomic shotgun sequencing, we investigated gut microbiota signatures associated with CAD and provided strain-resolved insights through metagenome-assembled genome (MAG) reconstruction. We analyzed 14 patients with CAD and 28 propensity score-matched healthy controls. Differential abundance analysis identified 15 CAD-associated bacterial species. Members of the

Indexed as

BacteriaCoronary Artery DiseaseGastrointestinal MicrobiomeMetabolic Networks and PathwaysMetagenomeAgedCase-Control StudiesFecesFemaleHumansMaleMetagenomicsMiddle Agedcardiovascular diseasecoronary artery diseasegut microbiomemetagenome-assembled genomeshotgun metagenomics

Identifiers

PMID41196050
PMCPMC12710354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.