Evidence map›Paper›PMID 41196049›Full record

ArticleNeurosurgery2026

Association Between Nutritional Status and Survival in Patients Requiring Treatment for Spinal Metastases.

Anne L Versteeg, Raphaële Charest-Morin, Rafael De La Garza Ramos, Ilya Laufer, William G J Teixeira, Ori Barzilai, Alessandro Gasbarrini, Michael G Fehlings, Dean Chou, Ziya L Gokaslan and 23 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Beyond albumin: a systematic review, meta-analysis, and GRADE assessment of seven preoperative nutritional and inflammatory biomarkers in metastatic spine surgery.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Anne L VersteegDepartment of Orthopaedics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-3251-9694
Raphaële Charest-MorinDepartment of Orthopaedics, University of British Columbia, Vancouver, British Columbia, Canada.
Rafael De La Garza RamosDepartment of Neurosurgery, Montefiore Medical Center, Albert Einstein College of Medicine, New York, New York, USA.
Ilya LauferDepartment of Neurosurgery, New York University Langone Health, New York, New York, USA.
William G J TeixeiraInstituto do Câncer do Estado de São Paulo, São Paulo , Brazil.
Ori BarzilaiDepartment of Neurosurgery, New York University Langone Health, New York, New York, USA.
Alessandro GasbarriniDepartment of Orthopaedics, IRCCS Istituto Ortopedico Rizzoli and Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Michael G FehlingsDepartment of Orthopaedics, University of Toronto, Toronto, Ontario, Canada.
Dean ChouDepartment of Neurosurgery, Columbia University Irving Medical Center, New York, New York, USA.
Ziya L GokaslanDepartment of Neurosurgery, Warren Alpert School of Medicine, Brown University, Providence, Rhode Island, USA.
Cordula NetzerDepartment of Orthopaedics, Universitätsspital Basel, Basel, Switzerland.
Alessandro LuzzatiDepartment of Orthopaedics, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
Jorrit-Jan VerlaanDepartment of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands.
Tony GoldschlagerDepartment of Neurosurgery, Monash University, Melbourne, Australia.
John H ShinDepartment of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
John E O'TooleDepartment of Neurosurgery, Rush University Medical Center, Chicago, Illinois, USA.
Daniel M SciubbaDepartment of Neurosurgery, Northwell Health, Manhasset, New York, USA.
Chetan BettegowdaDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Michelle J ClarkeDepartment of Neurologic Surgery, Mayo Clinic, Rochester , Minnesota , USA.
Michael H WeberDepartment of Orthopaedics, McGill University, Montreal, Quebec, Canada.
Addisu MesfinDepartment of Orthopaedics, Medstar Orthopaedic Institute, Georgetown University School of Medicine, Washington, District of Columbia, USA.
Norio KawaharaKanazawa Medical University, Uchinada , Ishikawa , Japan.
Shalin S PatelDepartment of Neurosurgery, The University of Texas Maryland Anderson Cancer Center, Houston, Texas, USA.
C Rory GoodwinDepartment of Neurosurgery, Duke University, Durham, North Carolina, USA.
Alexander C DischDepartment of Orthopaedics, University Hospital Carl Gustav Carus at the TU Dresden, Germany.
Jeremy J ReynoldsDepartment of Orthopaedics, Nuffield Orthopaedic Centre, Oxford, UK.
Aron LazaryDepartment of Orthopaedics, National Center for Spinal Disorders, Budapest, Hungary.
Stefano BorianiUniversity of Bologna, Bologna , Italy.
Nicolas DeaDepartment of Orthopaedics, University of British Columbia, Vancouver, British Columbia, Canada.
Arjun SahgalDepartment of Radiation Oncology, Sunnybrook Health Sciences Center, Toronto , Ontario , Canada.
Laurence D RhinesDepartment of Neurosurgery, The University of Texas Maryland Anderson Cancer Center, Houston, Texas, USA.
Charles G FisherDepartment of Orthopaedics, University of British Columbia, Vancouver, British Columbia, Canada.
AO Spine Knowledge Forum Tumor

Funding

AOSpine
6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe Patient-Generated Subjective Global Assessment (PG-SGA) is a standardized tool for assessing malnutrition in patients with cancer. The primary aim of this study was to assess the impact of preoperative nutritional status as measured by PG-SGA on survival in patients requiring surgical intervention and/or radiotherapy for spinal metastases.

methodsPatients with spinal metastases who underwent surgery and/or radiation therapy for symptomatic spinal metastases were enrolled in the AO Spine Metastatic Tumor Research and Outcomes Network, a prospective international multicenter research registry, between September 2017 and August 2022. Using the PG-SGA, nutritional status was classified into 3 categories: A, well nourished; B, moderately malnourished; and C, severely malnourished.

resultsA total of 589 patients met the inclusion criteria; 362 were classified as well nourished (61%), 159 were moderately malnourished (27%), and 68 were severely malnourished (12%). The median survival was 491 days, 328 days, and 117 days for well-nourished, moderately malnourished, and severely malnourished patients, respectively. In the multivariate analyses, severe malnourishment (HR 2.5 95% CI 1.4-4.3, P < .01) and an ECOG performance status of 3 or 4 (HR 2.7 95% CI 1.2-6.0) remained associated with significantly worse survival.

conclusionMalnutrition as measured by the PG-SGA demonstrated to be significantly and independently associated with postoperative survival. The PG-SGA is a simple and useful tool to identify spinal metastases patients at risk of early postoperative mortality, and inclusion in the preoperative evaluation of these patients should be considered.

Indexed as

MalnutritionNutritional StatusSpinal NeoplasmsAdultAgedFemaleHumansMaleMiddle AgedProspective StudiesNutritional statusRadiation therapySpinal metastasesSurgerySurvival

Identifiers

PMID41196049
PMCPMC13336674

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.