Evidence map›Paper›PMID 41196042›Full record

ArticlemSystems2025

Spatially divergent metabolic impact of experimental toxoplasmosis: immunological and microbial correlates.

Mahbobeh Lesani, Caitlyn E Middleton, Tzu-Yu Feng, Jan Carlos Urbán Arroyo, Eli Casarez, Sarah E Ewald, Laura-Isobel McCall

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mahbobeh Lesani *Department of Microbiology and Plant Biology, University of Oklahoma, Norman, Oklahoma, USA.
Caitlyn E Middleton *Department of Chemistry and Biochemistry, San Diego State University, San Diego, California, USA.ORCID 0009-0005-2179-0982
Tzu-Yu Feng *Department of Microbiology, Immunology and Cancer Biology at the Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Jan Carlos Urbán ArroyoDepartment of Microbiology, Immunology and Cancer Biology at the Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Eli CasarezDepartment of Microbiology, Immunology and Cancer Biology at the Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Sarah E EwaldDepartment of Microbiology, Immunology and Cancer Biology at the Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.ORCID 0000-0002-5327-7578
Laura-Isobel McCallDepartment of Chemistry and Biochemistry, San Diego State University, San Diego, California, USA.ORCID 0000-0002-1243-8953

Funding

Innate Inflammatory Control of CachexiaR35GM138381 · NIGMS · UNIVERSITY OF VIRGINIA · PI Sarah E. Ewald · 2020 to 2026
$2.9M
Burroughs Wellcome FundNIGMS NIH HHS R35 GM138381NIGMS NIH HHS R35GM138381Rees Stealy Research Foundation
6 · The paper itself

Abstract

Maladaptive host metabolic responses to infection are emerging as major determinants of infectious disease pathogenesis. However, the factors regulating these metabolic changes within tissues remain poorly understood. In this study, we used toxoplasmosis, as a prototypical example of a disease regulated by strong type I immune responses, to assess the relative roles of current local parasite burden, local tissue inflammation, and the microbiome in shaping local tissue metabolism during acute and chronic infections. Toxoplasmosis is a zoonotic disease caused by the parasite

Indexed as

ToxoplasmaToxoplasmosisToxoplasmosis, AnimalAnimalsDisease Models, AnimalFemaleMiceMice, Inbred C57BLMice, KnockoutMicrobiotainflammationmass spectrometrymetabolismmicrobiomeToxoplasma gondii

Identifiers

PMID41196042
PMCPMC12710369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.