Evidence map›Paper›PMID 41195954›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Grafting Cell-Penetrating Poly(disulfide)s to Substrates of Interest: Dynamic Covalent Bioconjugation for Traceless Delivery.

Michael Cognet, Giacomo Renno, Filipe Coelho, Naomi Sakai, Stefan Matile

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael Cognet *Department of Organic Chemistry, University of Geneva, Geneva, Switzerland.
Giacomo Renno *Department of Organic Chemistry, University of Geneva, Geneva, Switzerland.
Filipe CoelhoDepartment of Organic Chemistry, University of Geneva, Geneva, Switzerland.
Naomi SakaiDepartment of Organic Chemistry, University of Geneva, Geneva, Switzerland.
Stefan MatileDepartment of Organic Chemistry, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-8537-8349

Funding

National Centre of Competence in Research (NCCR) 51NF40-205608Swiss NSF 200020Swiss NSF 204175Swiss NSF TMAG-2_209190
6 · The paper itself

Abstract

Although increasingly understood and appreciated, thiol-mediated uptake (TMU) remains underused because practical traceless tags that solve daily delivery problems are not yet available. The most popular cell-penetrating poly(disulfide)s (CPDs) were initially introduced as traceless tags that could be grafted from any thiol-containing substrate of interest (SOI) in situ and would depolymerize in the cytosol right after uptake. This approach was operational but not ideal for solving practical problems because the concentrations of SOIs >30 µM needed in neutral water are above those acceptable in most biological studies. Here, we report that CPD grafting-to SOIs, rather than grafting-from, provides access to dynamic covalent cysteine bioconjugation with protein concentrations down to 50 nM, which is more than 600 times below standard grafting-from CPD chemistry. With rate constants up to 1500 M

Indexed as

Cell-Penetrating PeptidesDisulfidesCysteineHumansSulfhydryl CompoundsCell-Penetrating PeptidesCysteineDisulfidesSulfhydryl CompoundsBioconjugationCellular uptakeDynamic‐covalent chemistryPolymer chemistryProtein delivery

Identifiers

PMID41195954
PMCPMC12759256

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.