ArticleVeterinary pathology2026
Concurrent histological lesions and molecular detection of porcine circovirus 3 in pigs with skeletal abnormalities and humpy-back posture.
Article in Veterinary pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Porcine circovirus 3 (PCV-3) is associated with various pathological conditions, including systemic disease and reproductive disorders; however, its role in skeletal abnormalities has never been elucidated. This study included 36 cases displaying spinal malformations, rib swelling, head edema, gait abnormalities, and/or increased late-term abortions. Investigated animals consisted of 9 aborted fetuses, 9 piglets, 12 weaners, and 6 finishers. Histologically, PCV-3 associated lesions were identified in 23/36 cases (64%), including (peri-)arteritis and rib fractures with prominent callus formation. Central nervous system (CNS) lesions, in addition to vascular changes, comprised meningoencephalitis and gliosis. Thirteen animals (36%) did not display histological lesions. PCV-3 DNA was detected by real-time PCR (qPCR) in 25/36 animals (69%), with high viral loads in the bone and CNS. Three aborted fetuses tested positive for PCV-3 despite lacking macroscopic and histologic lesions.
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