Trial reportJournal of the American Heart Association2025
Endogenous Circadian System Attenuates Nighttime Vascular Endothelial Function in People With Untreated Obstructive Sleep Apnea.
Trial report in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02202811 (Circadian Rhythms and Cardiovascular Risk), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Circadian Rhythms and Cardiovascular Risk
Who cites it
1 citing paper in PubMed.
- Unlocking the potential of circadian biology for cardiovascular health.Physiological reviews · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundIn people with obstructive sleep apnea (OSA), adverse cardiovascular events, such as myocardial infarction, occur more commonly in the middle of the night than at other times of the day. These events could occur as a result of the nighttime physiological changes in OSA, but the endogenous circadian system has been implicated in increased cardiovascular risk in OSA. Vascular endothelial function is a marker of prospective cardiovascular risk and is impaired in OSA. We hypothesized that the nighttime risk in OSA could be due to a circadian system-driven nighttime impairment in vascular endothelial function.
methodsTwelve adults (healthy except for untreated moderate to severe OSA, 8 men and 4 women, 51± SD 7 years; apnea/hypopnea index, 29±19 hours of sleep) completed a 5-day circadian protocol consisting of 10 recurring 5-hour 20-minute periods (2 hours 40 minutes each of wake periods and sleep opportunities) to separate the circadian system's effects from those of behaviors such as exercise, meal intake, and sleep. We measured flow-mediated dilation of the brachial artery during each wake period in each participant.
resultsWe discovered a significant circadian rhythm in flow-mediated dilation (
conclusionsThese data suggest that the circadian system impairs vascular endothelial function during the biological night, potentially increasing vascular vulnerability in people with untreated OSA. REGISTRATION: URL: https://clinicaltrials.gov/; Unique Identifier: NCT02202811.
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Registered trials
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