Evidence map›Paper›PMID 41195779›Full record

ArticleJournal of the American Heart Association2025

Human Variant in the Cardiac Troponin I Switch Domain Causes Diastolic Dysfunction in a Novel Mouse Model.

Elizabeth Silver, Jason M Duran, Betul Beyza Gunes, Axel J Fenwick, Sofie Maisel, Tsui-Min Wang, Ana Maria Manso, Marina Sampaio Cruz, Yusu Gu, Joshua Fong and 16 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Elizabeth SilverDivision of Cardiovascular Medicine, Department of Medicine University of California San Diego La Jolla CA.ORCID 0009-0000-5605-0646
Jason M DuranDivision of Cardiovascular Medicine, Department of Medicine University of California San Diego La Jolla CA.ORCID 0000-0003-1666-2319
Betul Beyza GunesDivision of Cardiovascular Medicine, Department of Medicine University of California San Diego La Jolla CA.ORCID 0009-0004-9686-1952
Axel J FenwickDivision of Cardiology, Department of Medicine Johns Hopkins University Baltimore MD.ORCID 0000-0002-8296-537X
Sofie MaiselDivision of Cardiovascular Medicine, Department of Medicine University of California San Diego La Jolla CA.
Tsui-Min WangDepartment of Bioengineering University of California San Diego La Jolla CA.ORCID 0000-0002-0788-6065
Ana Maria MansoDivision of Cardiovascular Medicine, Department of Medicine University of California San Diego La Jolla CA.
Marina Sampaio CruzDivision of Cardiovascular Medicine, Department of Medicine University of California San Diego La Jolla CA.
Yusu GuSeaweed Canyon Physiology Core Laboratory University of California San Diego La Jolla CA.ORCID 0000-0002-9543-8472
Joshua FongDivision of Cardiovascular Medicine, Department of Medicine University of California San Diego La Jolla CA.
Aysen ShathayaDivision of Cardiovascular Medicine, Department of Medicine University of California San Diego La Jolla CA.
Chao ChenDivision of Cardiovascular Medicine, Department of Medicine University of California San Diego La Jolla CA.
Angel Soto-HermidaDivision of Cardiovascular Medicine, Department of Medicine University of California San Diego La Jolla CA.
Wei FengDivision of Cardiovascular Medicine, Department of Medicine University of California San Diego La Jolla CA.ORCID 0000-0002-9106-4258
Yoshitake ChoDivision of Cardiovascular Medicine, Department of Medicine University of California San Diego La Jolla CA.ORCID 0000-0002-7161-3248
Julius BogomolovasDivision of Cardiovascular Medicine, Department of Medicine University of California San Diego La Jolla CA.ORCID 0000-0001-8344-1909
Jill M GelowProvidence Heart Institute Providence St. Vincent Medical Center Portland OR.
Ahmad MasriOregon Health and Science University Portland OR.ORCID 0000-0002-6390-6526
Kelly A FrazerDepartment of Pediatrics University of California San Diego La Jolla CA.ORCID 0000-0002-6060-8902
Robert S RossDivision of Cardiovascular Medicine, Department of Medicine University of California San Diego La Jolla CA.ORCID 0000-0003-2195-8982
Ju ChenDivision of Cardiovascular Medicine, Department of Medicine University of California San Diego La Jolla CA.ORCID 0000-0001-7674-4776
Catherine A MakarewichThe Heart Institute, Division of Molecular Cardiovascular Biology Cincinnati Childrens Hospital Medical Center Cincinnati OH.ORCID 0000-0001-6907-4401
Anthony CammaratoDivision of Cardiology, Department of Medicine Johns Hopkins University Baltimore MD.ORCID 0000-0003-1104-4407
Andrew D McCullochDivision of Cardiovascular Medicine, Department of Medicine University of California San Diego La Jolla CA.ORCID 0000-0002-1708-5675
Paul BushwayDivision of Cardiovascular Medicine, Department of Medicine University of California San Diego La Jolla CA.ORCID 0009-0009-0123-7687
Eric D AdlerDivision of Cardiovascular Medicine, Department of Medicine University of California San Diego La Jolla CA.ORCID 0000-0002-4765-0188

Funding

REGULATORY GENOMIC STUDIES IN A COHORT OF IPS CELL DERIVED CARDIOMYOCYTESU01HL107442 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EVANS, SYLVIA M, FRAZER, KELLY A · 2011 to 2016
$9.8M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
PATHOGENESIS AND IN VIVO SUPPRESSION OF THIN FILAMENT-BASED CARDIOMYOPATHIESR01HL124091 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Anthony Cammarato · 2015 to 2026
$4.3M
The role of obscurin and Obsl1 as key determinants for diastolic functionR01HL152251 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHO, YOSHITAKE, LANGE, STEPHAN · 2021 to 2024
$2.3M
PERM in Cardiac FunctionR01HL151239 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHO, YOSHITAKE, ROSS, ROBERT SCOTT · 2020 to 2023
$1.6M
Pathogenesis and in vivo suppression of thin filament based cardiomyopathiesR56HL124091 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CAMMARATO, ANTHONY · 2014 to 2014
$383k
NHLBI NIH HHS R01 HL124091NHLBI NIH HHS R01 HL151239NHLBI NIH HHS R01 HL152251NHLBI NIH HHS R56 HL124091NHLBI NIH HHS U01 HL107442NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cardiomyopathiescardiomyopathy, restrictiveechocardiographymicesarcomerestroponin I

Identifiers

PMID41195779
PMCPMC12887218

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.