Evidence map›Paper›PMID 41195728›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2025

Epigenetic age and telomere length correlations in pediatric-onset multiple sclerosis.

Jennifer H Yang, Jonathan Race, Paige Sumowski, Kayla Jacques, Soha Fardad, Ashley Fair, Allison Hazlett, Jue Lin, Defne Yilmaz, Gregory Aaen and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Jennifer H YangDivision of Pediatric Neurology, Rady Children's Hospital San Diego, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-5438-7210
Jonathan RaceUniversity of Utah Health, Salt Lake City, UT, USA.ORCID 0000-0001-9423-5131
Paige SumowskiDivision of Pediatric Neurology, Rady Children's Hospital San Diego, University of California San Diego, La Jolla, CA, USA.
Kayla JacquesDivision of Pediatric Neurology, Rady Children's Hospital San Diego, University of California San Diego, La Jolla, CA, USA.
Soha FardadDivision of Pediatric Neurology, Rady Children's Hospital San Diego, University of California San Diego, La Jolla, CA, USA.
Ashley FairBoston University, Boston, MA, USA.
Allison HazlettUniversity of Utah Health, Salt Lake City, UT, USA.ORCID 0000-0003-0968-0340
Jue LinUniversity of California San Francisco, San Francisco, CA, USA.
Defne YilmazUniversity of California Berkeley, Berkeley, CA, USA.ORCID 0009-0009-0083-4797
Gregory AaenLoma Linda University, Loma Linda, CA, USA.
Aaron AbramsThe Cleveland Clinic Mellen Center, Cleveland, OH, USA.ORCID 0000-0002-4607-5740
Leslie BensonBoston Children's Hospital, Boston, MA, USA.
T Charlie CasperUniversity of Utah Health, Salt Lake City, UT, USA.
Tanuja ChitnisBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Mark GormanBoston Children's Hospital, Boston, MA, USA.
Timothy LotzeTexas Children's, Houston, TX, USA.
Lauren KruppNYU Langone Health, New York, USA.ORCID 0000-0001-7003-807X
Soe MarWashington University St. Louis, St. Louis, MO, USA.
Jayne NessUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Mary RenselThe Cleveland Clinic Mellen Center, Cleveland, OH, USA.ORCID 0000-0001-9613-8394
John RoseUniversity of Utah Health, Salt Lake City, UT, USA.
Teri SchreinerUniversity of Colorado Anschutz Campus, Aurora, CO, USA.ORCID 0000-0002-3816-812X
Jan-Mendelt TillemaThe Mayo Clinic, Rochester, MN, USA.
Amy WaldmanChildren's Hospital of Philadelphia, Philadelphia, PA, USA.
Yolanda WheelerUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Lisa F BarcellosUniversity of California Berkeley, Berkeley, CA, USA.
Emmanuelle WaubantUniversity of California San Francisco, San Francisco, CA, USA.
Jennifer S GravesDivision of Pediatric Neurology, Rady Children's Hospital San Diego, University of California San Diego, La Jolla, CA, USA; Rady Children's Pediatric MS Center, San Diego, CA, USA.

Funding

Child Neurologist Career Development Program (CNCDP)K12NS098482 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI SCHLAGGAR, BRADLEY L · 2016 to 2025
$26.2M
Environmental and genetic risk factors for pediatric MSR01NS071463 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WAUBANT, EMMANUELLE LAURENCE · 2010 to 2015
$2.8M
NINDS NIH HHS K12 NS098482NINDS NIH HHS L40 NS139363NINDS NIH HHS R01 NS071463
6 · The paper itself

Abstract

backgroundAge is the strongest factor determining disease expression in multiple sclerosis (MS). We previously demonstrated biological age acceleration in pediatric-onset MS (POMS) compared to controls with both epigenetic clocks (DNAm) and telomere length (TL). It is unknown whether these markers report overlapping or distinct aging-related processes.

objectivesTo determine the correlation between DNAm and TL aging markers.

methodsWe conducted a cross-sectional case-control study within the US Network of Pediatric MS Centers. We calculated age acceleration residuals for the Horvath, Hannum, PhenoAge, and GrimAge epigenetic clocks and measured TL from whole blood samples to estimate telomere to somatic DNA ratios (T/S ratio). We employed multivariable analysis of covariance to assess the correlation between DNAm estimates and TL.

resultsWe analyzed biological ages in 270 participants (125 POMS, mean 15.7 years; 145 controls, mean 15.3 years). There were moderate correlations among the different DNAm clocks, but no correlations between DNAm clocks and TL in pooled analyses. In a stratified analysis, only the control group showed a modest correlation between TL and PhenoAge clock (

conclusionsDNAm did not correlate with TL in this sample of POMS and controls, suggesting that these biomarkers may capture complementary and non-overlapping elements of aging-related biology.

Indexed as

AgingEpigenesis, GeneticMultiple SclerosisTelomereTelomere HomeostasisAdolescentAge of OnsetCase-Control StudiesChildCross-Sectional StudiesDNA MethylationFemaleHumansMaleYoung AdultAgingbiomarkersepigeneticMSpediatricstelomeres

Identifiers

PMID41195728
PMCPMC12614491

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.