Evidence map›Paper›PMID 41195309›Full record

ArticlePediatric diabetes2025

HLA-C

Zhenran Xu, Xiaojing Li, Xiaoxiao Yuan, Chengjun Sun, Miaoying Zhang, Ruimin Chen, Haiyan Wei, Linqi Chen, Hongwei Du, Guimei Li and 7 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zhenran XuDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID 0000-0003-2718-6717
Xiaojing LiDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Xiaoxiao YuanDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID 0000-0003-2405-0101
Chengjun SunDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID 0000-0001-6025-4801
Miaoying ZhangDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID 0000-0002-4160-3962
Ruimin ChenDepartment of Endocrinology and Inherited Metabolic, Fuzhou Children's Hospital of Fujian Medical University, Fuzhou, China.
Haiyan WeiDepartment of Endocrinology and Inherited Metabolic, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.ORCID 0000-0003-1044-6594
Linqi ChenDepartment of Endocrinology and Inherited Metabolic, Children's Hospital of Soochow University, Suzhou, China.
Hongwei DuDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, The First Hospital of Jilin University, Changchun, China.
Guimei LiDepartment of Pediatric Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.ORCID 0000-0001-8372-3842
Yu YangDepartment of Endocrinology and Inherited Metabolic, The Affiliated Children's Hospital of Nanchang University, Nanchang, China.
Xiaojuan ChenDepartment of Endocrinology, Genetics and Metabolism, The Children's Hospital of Shanxi Province, Taiyuan, China.
Lanwei CuiDepartment of Pediatrics, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Xin FangDepartment of Pediatrics, Fujian Medical University Union Hospital, Fuzhou, China.
Jing WuDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Qiuyue LiDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Feihong LuoDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.ORCID 0000-0002-6433-7994

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate whether human leukocyte antigens (HLAs) influence gut microbiota composition and contributes to delayed type 1 diabetes mellitus (T1DM) onset in children. Methods: This multicenter cross-sectional study included 106 newly diagnosed pediatric T1DM patients (age <18 years) and 69 healthy controls from nine Chinese cities. Gut microbiota was profiled via whole-metagenome shotgun sequencing, and HLA alleles were genotyped by PCR sequence-based typing. Participants were stratified by HLA-risk scores. Statistical analyses included α/β-diversity metrics, linear discriminant analysis effect size analysis (LEfSe), and Spearman correlation adjusted for confounders. Results: Principal coordinates analysis (PCoA) exposed discernible disparities in gut microbiota structures within the high-HLA-risk T1DM cohort relative to both high- and low-HLA-risk control groups ( Conclusions: Our study demonstrates that specific HLA class I subtypes (e.g., C

Indexed as

Diabetes Mellitus, Type 1Gastrointestinal MicrobiomeAdolescentAge of OnsetChildChild, PreschoolCohort StudiesCross-Sectional StudiesFemaleHumansInfantMalegut microbiotahuman leukocyte antigentype 1 diabetes

Identifiers

PMID41195309
PMCPMC12585876

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.