Evidence map›Paper›PMID 41195302›Full record

ArticleNPJ dementia2025

Voiceprints of cognitive impairment: analyzing digital voice for early detection of Alzheimer's and related dementias.

Neguine Rezaii, Bonnie Wong, Paul Aisen, Laurel Beckett, Jeffrey L Dage, Ani Eloyan, Tatiana Foroud, Kyle Womack, Maria C Carrillo, Joel H Kramer and 37 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ dementia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors.

Neguine RezaiiDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA.
Bonnie WongDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA.
Paul AisenAlzheimer's Therapeutic Research Institute, University of Southern California, San Diego, CA USA.
Laurel BeckettDepartment of Public Health Sciences, University of California - Davis, Davis, CA USA.
Jeffrey L DageDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN USA.
Ani EloyanDepartment of Biostatistics, Center for Statistical Sciences, Brown University, Providence, RI USA.
Tatiana ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN USA.
Kyle WomackDepartment of Neurology, Washington University in St. Louis, St. Louis, MO USA.
Maria C CarrilloMedical & Scientific Relations Division, Alzheimer's Association, Chicago, IL USA.
Joel H KramerDepartment of Neurology, University of California - San Francisco, San Francisco, CA USA.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, MN USA.
Robert KoeppeDepartment of Radiology, University of Michigan, Ann Arbor, MI USA.
Walter A KukullDepartment of Epidemiology, University of Washington, Seattle, WA USA.
Kelly NudelmanDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN USA.
Angelina J PolsinelliDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN USA.
Rema RamanAlzheimer's Therapeutic Research Institute, University of Southern California, San Diego, CA USA.
Malia RumbaughDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN USA.
Alexander TauroneDepartment of Biostatistics, Center for Statistical Sciences, Brown University, Providence, RI USA.
Maryanne ThangarajahDepartment of Biostatistics, Center for Statistical Sciences, Brown University, Providence, RI USA.
Arthur TogaLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Los Angeles, CA USA.
Prashanthi VemuriDepartment of Radiology, Mayo Clinic, Rochester, MN USA.
Alireza AtriBanner Sun Health Research Institute, Sun City, AZ USA.
David ClarkDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN USA.
Gregory S DayDepartment of Neurology, Mayo Clinic in Florida, Jacksonville, FL USA.
Ranjan DuaraWien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami, FL USA.
Neill R Graff-RadfordDepartment of Neurology, Mayo Clinic in Florida, Jacksonville, FL USA.
Ian GrantDepartment of Psychiatry and Behavioral Sciences, Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL USA.
Lawrence S HonigTaub Institute and Department of Neurology, Columbia University Irving Medical Center, New York, NY USA.
Erik C B JohnsonDepartment of Neurology and Human Genetics, Emory University School of Medicine, Atlanta, GA USA.
David T JonesDepartment of Neurology, University of California - San Francisco, San Francisco, CA USA.
Joseph C MasdeuNantz National Alzheimer Center, Houston Methodist and Weill Cornell Medicine, Houston, TX USA.
Mario F MendezDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA USA.
Erik MusiekDepartment of Neurology, Washington University in St. Louis, St. Louis, MO USA.
Chiadi U OnyikeDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD USA.
Meghan RiddleDepartment of Neurology, Alpert Medical School, Brown University, Providence, RI USA.
Emily RogalskiDepartment of Neurology, University of Chicago School of Medicine, Chicago, IL USA.
Steven SallowayDepartment of Neurology, Alpert Medical School, Brown University, Providence, RI USA.
Sharon ShaDepartment of Neurology & Neurological Sciences, Stanford University, Palo Alto, CA USA.
R Scott TurnerDepartment of Neurology, Georgetown University, Washington, D. C. USA.
Thomas S WingoDepartment of Neurology and Human Genetics, Emory University School of Medicine, Atlanta, GA USA.
David A WolkDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.
Dustin HammersDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN USA.
Kala KirbyDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN USA.
Gil D RabinoviciDepartment of Neurology, University of California - San Francisco, San Francisco, CA USA.
Liana G ApostolovaDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN USA.
Bradford C DickersonDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA.
LEADS Consortium

Funding

National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
Early Onset AD Consortium - the LEAD Study (LEADS)U01AG057195 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI APOSTOLOVA, LIANA G, CARRILLO, MARIA C · 2018 to 2023
$70.3M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
Satellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3M
THE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI BANDEEN-ROCHE, KAREN J. · 1985 to 2019
$37.6M
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie · 2019 to 2026
$36.5M
UPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI VAN DEERLIN, VIVIANNA M · 1991 to 2020
$35.1M
Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHILIP L DE JAGER · 2020 to 2026
$30.1M
NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG062421NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066506NIA NIH HHS P30 AG072976NIA NIH HHS P50 AG005134NIA NIH HHS P50 AG005146NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG008702NIA NIH HHS P50 AG023501NIA NIH HHS P50 AG025688NIA NIH HHS P50 AG047366NIA NIH HHS R21 AG073744NIA NIH HHS R56 AG057195NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG057195NIA NIH HHS U24 AG021886NIDCD NIH HHS R21 DC019567NINDS NIH HHS R01 NS131395NINDS NIH HHS RF1 NS131395
6 · The paper itself

Abstract

Early detection of Alzheimer's disease (AD) is critical yet challenging, particularly in younger individuals. This study leverages artificial intelligence to analyze digital voice recordings from the Craft Story Recall task within the Longitudinal Early-onset AD Study (LEADS) to (1) detect cognitive impairment and (2) differentiate early-onset AD (EOAD) from early onset non-AD cognitive impairment (EOnonAD). Using speech samples from 120 patients and 68 cognitively unimpaired controls, we employed two classification approaches: feature-engineered machine learning and end-to-end deep learning incorporating a Large Language Model. To detect mild cognitive impairment, the feature-engineered model, using acoustic and linguistic features, achieved an AUC of 0.945 on the holdout test set, while the end-to-end model yielded an AUC of 0.988. For differentiating EOAD from EOnonAD, the feature-engineered model achieved an AUC of 0.804, and the end-to-end model yielded an AUC of 0.904 on the holdout set. Explainability analyses revealed reduced linguistic informativeness as a key AD indicator.

Indexed as

Computational biology and bioinformaticsDiseasesNeurologyNeuroscience

Identifiers

PMID41195302
PMCPMC12583127

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.