ArticleFrontiers in medicine2025
Comparative efficacy of intravitreal aflibercept biosimilar QL1207 versus reference aflibercept in the treatment of diabetic macular edema.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Biosimilars of anti-VEGF agents in retinal diseases: a narrative review of regulatory, clinical, and pharmacoeconomic aspects.International journal of retina and vitreous · 2026Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aims to comparatively evaluate the clinical efficacy of intravitreal injections of aflibercept biosimilar QL1207 and the reference aflibercept in the treatment of diabetic macular edema (DME). Methods: This retrospective study analyzed the clinical data of 80 patients (80 eyes) with DME who underwent initial treatment at our hospital's Department of Ophthalmology between June 2023 and April 2024. Forty patients (40 eyes) received intravitreal injections of the reference aflibercept (aflibercept group). Forty patients (40 eyes) were treated with intravitreal injections of the aflibercept biosimilar QL1207 (QL1207 group). All patients received a 3 + PRN (pro re nata) treatment regimen and completed a minimum follow-up period of 12 months. Best-corrected visual acuity (BCVA), optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA) were assessed before and after treatment. BCVA and central retinal thickness (CRT) were compared between the two groups at baseline and at 1-, 3-, 6-, and 12-month post-treatment. Additionally, the foveal avascular zone (FAZ) area, macular vessel density, the number of intravitreal injections required, and the incidence of adverse reactions were evaluated before and 12 months after treatment. Results: The intergroup comparison of BCVA and CRT before and after treatment showed no statistically significant differences ( Conclusion: Both the reference aflibercept and its biosimilar QL1207 demonstrate comparable efficacy in the treatment of DME, effectively reducing macular edema, improving BCVA, and enhancing macular perfusion status.
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