ArticleFrontiers in medicine2025
Increased propofol consumption with later anesthesia start times in sedated gastrointestinal endoscopy: insights from regression and machine learning models.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Chronopharmacology is an important but underexplored aspect of propofol administration. Despite the implementation of propofol administration models, none have yet incorporated temporal variables. This study aims to investigate the impact of temporal variations on propofol administration during sedated gastrointestinal (GI) endoscopy. Moreover, we aim to develop regression models to predict manually-controlled propofol administration that integrate temporal variables. Methods: This prospective single-center cohort study enrolled patients undergoing sedated GI endoscopy. For analysis, patients were categorized into 4 groups based on the anesthesia start time: Group 1 (8:00-10:00), Group 2 (10:00-12:00), Group 3 (13:00-15:00), and Group 4 (15:00-17:00). Perioperative characteristics and propofol doses were compared across groups. Correlation analysis was conducted to evaluate the relationship between propofol dose and the anesthesia start time. Subsequently, linear regression models were developed for manually-controlled propofol administration. Results: A total of 146 cases were included in the statistical analysis. Significant differences were found for all parameters related to propofol dose across the 4 different groups, including induction dose, maintenance dose, total dose and these doses per kilogram per hour. Furthermore, there were positive correlations between the anesthesia start time and all parameters. In the linear regression models, the induction dose equation incorporated the anesthesia start time, age and weight as variables. The model of the maintenance dose per kilogram per hour included the anesthesia start time, duration and weight as variables. Conclusion: The results suggest that propofol dose increases with later anesthesia start times. Therefore, further clinical administration of propofol should incorporate a heightened consideration of temporal factors. Trial registration: This prospective study has been registered in the Chinese Clinical Trial Registry (Registration date: December 3, registry number ChiCTR2400093328).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.