ArticleFrontiers in medicine2025
Serum VEGF and ANGPT1 as angiogenesis markers may predict the outcomes of older adults with hip fractures.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Role of Endothelial Dysfunction in Fracture Healing: Mechanisms and Potential Effects on Skeletal Repair.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aims to investigate the potential of serum Vascular Endothelial Growth Factor (VEGF) and Angiopoietin 1 (ANGPT1) as angiogenesis markers to predict the outcomes of older adults with hip fractures. Methods: An observational study was conducted at the Emergency Trauma Center of Nanyang Second People's Hospital. Serum VEGF and ANGPT1 were measured on the first morning after surgery. Patients were followed up for 1 year to assess survival status and the ability to walk freely at 3, 6, and 12 months post-surgery. Receiver operating characteristic (ROC) curves were constructed to determine the predictive power of these markers, and propensity score matching (PSM) was performed to account for confounding factors. Multivariate Cox regression and logistic regression models were used to further analyze the prognostic roles of these markers. Results: The study cohort included 380 patients, with a mean age of 75.71 ± 8.58 years and a mortality rate of 17.11% within 1 year. Kaplan-Meier survival analysis revealed that low levels of VEGF and ANGPT1 were significantly associated with decreased survival probability. Multivariate Cox regression models indicated that low VEGF and ANGPT1 were independent risk factors for one-year mortality, while ANGPT2 did not show significant prognostic value. Conclusion: Elevated serum levels of VEGF and ANGPT1 are associated with improved outcomes in older adults with hip fractures, highlighting the importance of angiogenesis in fracture healing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.