ArticleFrontiers in medicine2025
The impact of seasonal variations on IVF pregnancy outcomes: a retrospective cohort study in Jinan, China.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: To evaluate the association between seasonal temperature variations and clinical outcomes of Methods: This retrospective cohort study analyzed 2,551 first fresh IVF-embryo transfer (IVF-ET) cycles performed at a tertiary reproductive center of The First Affiliated Hospital of Shandong University of Traditional Chinese Medicine between January 2009 and January 2024. The study population comprised normo-ovulatory women aged < 35 years without uterine anomalies or severe male factor infertility (sperm concentration >1 × 106/mL). Cycles were stratified into four seasonal cohorts based on gonadotropin initiation dates: spring (March-May, Results: Compared with the winter control group, risk of miscarriage in cycles initiated in spring showed a statistically significant increase (95% CI 1.019, 2.846; Conclusion: Seasonal microenvironmental factors during ovarian stimulation may modulate IVF success trajectories, suggesting potential benefits of climate-adaptive protocol personalization in temperate monsoon regions. Clinical trial registration: This is a retrospective case-control study.
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