ArticleFrontiers in cardiovascular medicine2025
Sex-differences in endotoxemia and trimethylamine N-oxide according to the diet and type 2 diabetes status in coronary heart disease patients: from the CORDIOPREV study.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Sex differences in the gut microbiome and related metabolites: role in cardiometabolic disease.Gut microbes · 2026Review
- Endotoxins and Metabolic Endotoxemia in Obesity and Associated Noncommunicable Diseases: A Focus on Sex Differences.Biomolecules · 2026Review
- Effects of QiShenYiQi dropping pills on gut dysbiosis and statin-associated muscle symptoms in ApoEFrontiers in cell and developmental biology · 2026Article
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14 authors.
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Abstract
Background: Cardiovascular disease (CVD) develops in men earlier in life but CVD women have a higher risk of cardiovascular mortality than CVD men. In addition, co-occurrence with type 2 diabetes mellitus (T2DM) increases CVD risk. We aimed to evaluate sex differences in endotoxemia and trimethylamine N-oxide (TMAO) plasma levels, in co-occurrence with T2DM in coronary heart disease (CHD) patients, and their potential sex-specific modulation by the consumption of healthy diets. Methods: This study was carried out within the framework of the CORDIOPREV study, a clinical trial which included 1,002 (827 men and 175 women) with CHD, of whom 462 had no T2DM, 350 had T2DM, and 190 were newly diagnosed with T2DM at recruitment. Plasma lipopolysaccharide (LPS) was measured by LAL colorimetric assay and TMAO by HPLC. Intima-media thickness of both common carotid arteries (IMT-CC) and carotid plaques were assessed ultrasonically. Results: LPS and TMAO plasma levels were lower in CHD non-T2DM women than CHD non-T2DM men (both, Conclusions: Our results suggest that the sex differences in CHD patients are influenced by the presence of T2DM. Moreover, our results also suggest that the cardiovascular risk associated to T2DM, in co-occurrence with CVD, is higher in women than in men.
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