Evidence map›Paper›PMID 41194980›Full record

ArticleFrontiers in bioengineering and biotechnology2025

Reperfused human umbilical cords as an

Camila Hoyos Banchon, Jan Heyer, Juliette S van Haren, Thorsten Orlikowsky, Ulrich Steinseifer, Sebastian V Jansen, Mark Schoberer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Reperfused human umbilical cords: hydrodynamic and hemolytic analysis of theFrontiers in bioengineering and biotechnology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Camila Hoyos Banchon *Pediatric Clinic, Neonatology Section, Faculty of Medicine, RWTH Aachen University and University Hospital, Aachen, Germany.
Jan Heyer *Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University and University Hospital, Faculty of Medicine, Aachen, Germany.
Juliette S van HarenDepartment of Industrial Design, Eindhoven University of Technology, Eindhoven, Netherlands.
Thorsten OrlikowskyDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University and University Hospital, Faculty of Medicine, Aachen, Germany.
Ulrich SteinseiferDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University and University Hospital, Faculty of Medicine, Aachen, Germany.
Sebastian V Jansen *Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University and University Hospital, Faculty of Medicine, Aachen, Germany.
Mark Schoberer *Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University and University Hospital, Faculty of Medicine, Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Establishing an extracorporeal circuit for artificial placenta technologies requires the cannulation of the umbilical vessels with large-bore cannulas. So far, this procedure could only be performed in large-animal models. We present the methodology and a novel test setup for reperfusion of human umbilical cords to develop and train cannulation procedures. Methods: 67 umbilical cords and placentas were harvested during cesarian sections, 15 cm umbilical cord specimen and fetal blood were used for these experiments. All three umbilical vessels were flushed, terminal cannulated, and connected to a circuit. We performed systematic validation tests on reperfusion of 15 umbilical cord specimens, followed by an ECMO cannulation of all three reperfused vessels. Results: The terminal cannulation succeeded in 43 of 67 cases. 15 of these were included in the validation study. A physiological flow of 71.2 mL/min ±3.9 mL/min (mean ± SD) could be established. ECMO Cannulation of at least one artery and one vein succeeded in 9 of 15 cases, and cannulation of all three vessels in five cases. Conclusion: Reperfusion of human umbilical cord specimens with fetal blood can provide a biosimilar model for the development, testing, and training of umbilical vessel cannulation with large-bore cannulas.

Indexed as

artificial placentaECMO cannulationextremely preterm infantsex vivo umbilical cord setuphuman umbilical cord

Identifiers

PMID41194980
PMCPMC12583208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.