Evidence map›Paper›PMID 41194975›Full record

ArticleJournal of diabetes research2025

Determinants of Femur and Tibia Fragility in Diabetes Using Dexamethasone-Induced Insulin Resistance in Rats.

Cheikh Ahmadou Bamba Mané, Maïmouna Touré, Cedric Wamba Koho, Herman Roger Sadie Foguieng, Khady Ngom, Hassane Malam Moussa Ahmet, Elvine Pami Nguelefack-Mbuyo, Abdoulaye Ba, Abdoulaye Samb, Télesphore Benoît Nguelefack

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cheikh Ahmadou Bamba ManéLaboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal.ORCID https://orcid.org/0009-0003-5942-2486
Maïmouna TouréLaboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal.ORCID https://orcid.org/0000-0003-1954-0210
Cedric Wamba KohoResearch Unit of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, Dschang, Cameroon.
Herman Roger Sadie FoguiengResearch Unit of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, Dschang, Cameroon.
Khady NgomLaboratory of Pathological Anatomy, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal.
Hassane Malam Moussa AhmetLaboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal.
Elvine Pami Nguelefack-MbuyoResearch Unit of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, Dschang, Cameroon.ORCID https://orcid.org/0000-0002-5754-7686
Abdoulaye BaLaboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal.
Abdoulaye SambLaboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal.
Télesphore Benoît NguelefackResearch Unit of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, Dschang, Cameroon.ORCID https://orcid.org/0000-0002-5006-6927

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes, mainly driven by insulin resistance (IR), represents 90% of diabetic cases and has been related to bone fragility and fractures. However, it is unclear how hyperglycaemia, IR and oxidative stress interplay to induce bone fragility. This study was then undertaken to examine the contribution and the interconnection of hyperglycaemia, insulinopenia, IR and oxidative stress to bone fragility, as well as the time- and severity-dependent effects of insulin impairment on bone fragility and its reversibility. IR was induced by dexamethasone in three different protocols: 1 mg/kg/day/im for 7 consecutive days; 500

Indexed as

DexamethasoneDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2FemurInsulin ResistanceTibiaAnimalsBlood GlucoseHyperglycemiaInsulinMaleOxidative StressRatsRats, WistarBlood GlucoseDexamethasoneInsulinbone fragilitydexamethasoneinsulin resistanceoxidative stress

Identifiers

PMID41194975
PMCPMC12585827

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.