ArticleStem cells international2025
miR-200a-3p in Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Attenuates UVB-Induced Skin Inflammatory Response and Oxidative Stress via Keap1-Nrf2 Pathway.
Article in Stem cells international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Mesenchymal Stem Cell-Derived Exosomes in Skin Wound Healing and Scar Prevention: Mechanisms, Comparison, and Clinical Prospects.Tissue engineering and regenerative medicine · 2026Review
- Stem cell-derived extracellular vesicles for high-altitude skin injuries: pathological mechanisms, advanced Nano-delivery, and translational perspectives.Frontiers in bioengineering and biotechnology · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultraviolet (UV) radiation induces skin damage primarily through oxidative stress and excessive inflammation. Exosomes derived from mesenchymal stem cells have emerged as promising therapeutic agents for tissue repair. Here, we investigated the protective effects of human umbilical cord mesenchymal stem cell-derived exosomes (HuMSC-Exos) on UVB-induced skin injury in HaCaTs and C57BL/6 mice. HuMSC-Exos significantly reduced reactive oxygen species (ROS) levels, suppressed proinflammatory cytokines (IL-1β, TNF-α, and IL-6), and improved cell migration. Mechanistically, HuMSC-Exos inhibited Keap1, enhanced both total and phosphorylated Nrf2 expression, promoted its nuclear translocation, and upregulated antioxidant genes (
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